Noradrenaline Bitartrate Suppliers & Bulk Manufacturers

Available Forms: Injection / infusion

Available Strengths: 2 mg / mL, 1mg/ml, 0.08 mg/mL

Reference Brands: Levophed (USA)

Category: Critical Care

Noradrenaline bitartrate is a potent vasopressor and adrenergic agonist used in critical care and emergency settings. It acts primarily on α-adrenergic receptors to cause vasoconstriction, thereby increasing blood pressure, with mild β1-adrenergic effects to support cardiac output.

Product Description:

Noradrenaline is the body's principal vasoconstrictor neurotransmitter, given as a drug to restore blood pressure when circulatory failure is life-threatening. It acts mainly on alpha-1 receptors in blood vessels, tightening them and raising systemic vascular resistance, with modest beta-1 activity that supports cardiac output without causing the tachycardia that dopamine and adrenaline produce.

It is the first-choice vasopressor in septic shock, recommended over dopamine because trials showed fewer arrhythmias and, in cardiogenic shock, better survival. It is also used in other distributive and vasodilatory shock states. It must be given by continuous infusion, titrated to a mean arterial pressure target, and preferably through a central line: extravasation from a peripheral vein causes intense local vasoconstriction and tissue necrosis, treated with local phentolamine. Excessive doses cause organ and limb ischaemia, and it should not be used in uncorrected hypovolaemia, where fluid is what is needed.

Sourcing notes. A critical hospital medicine on essential medicines lists, and one with a history of shortages and, in some markets, steep price rises. Concentrations differ between products, which is a documented source of dosing error, so the concentration and the diluent instructions must be clear. The solution is light-sensitive and oxidises, so ampoules and vials need protective packaging.