Macitentan Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 10 mg

Reference Brands: Opsumit (USA)

Category: Heart Disorder

Product Description:

Macitentan is an orally active, non-peptide dual endothelin receptor antagonist developed by Actelion and marketed under the brand name Opsumit. It selectively blocks both endothelin receptor subtypes, ETA and ETB, with a markedly higher affinity for the ETA receptor, which plays a key role in vasoconstriction and vascular remodeling in pulmonary arterial hypertension (PAH). By inhibiting endothelin-mediated pathways, macitentan helps reduce pulmonary vascular resistance and disease progression.

Opsumit is indicated for the long-term treatment of pulmonary arterial hypertension in adults classified as World Health Organization Functional Class II or III. It is used to reduce morbidity in patients with idiopathic or heritable PAH, as well as PAH associated with connective tissue disease or congenital heart disease. Macitentan can be administered as monotherapy or in combination with phosphodiesterase-5 inhibitors. It is available as 10 mg film-coated tablets, taken once daily, and is designed for sustained efficacy and improved tolerability in chronic PAH management.