Moexipril Hydrochloride 7.5 mg, 15 mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 7.5 mg, 15 mg

Reference Brands: Univasc (USA)

Category: Heart Disorder

Moexipril hydrochloride 7.5 mg and 15 mg tablets, an ACE inhibitor for hypertension taken before meals, for importers, distributors and hospital buyers in markets where the molecule is registered.

Product Description:

Moexipril hydrochloride is an ACE inhibitor supplied as 7.5 mg and 15 mg film-coated tablets. It is a prodrug: after absorption it is converted to moexiprilat, which blocks the enzyme that turns angiotensin I into angiotensin II. With less angiotensin II, arteries relax and aldosterone falls, so blood pressure drops. Reduced breakdown of bradykinin adds to the effect and explains the dry cough seen across the class. Food lowers its absorption, which shapes how the tablet is taken.

Its approved use is hypertension, alone or with a thiazide diuretic, with which it also comes as a combination tablet. The usual starting dose is 7.5 mg once daily, taken about one hour before a meal. Patients on a diuretic or with reduced kidney function start lower. It is contraindicated in pregnancy and after previous angioedema. Pharmacists check potassium and creatinine and watch for potassium-sparing diuretics, potassium supplements, NSAIDs, lithium and aliskiren. First-dose hypotension is most likely in salt- or volume-depleted patients.

Sourcing notes. Moexipril is registered in fewer markets than the common ACE inhibitors, so confirm current registration and reference product status before tendering. Expect a CTD or ACTD dossier with bioequivalence data and stability for your climatic zone, zone IVb for hot humid markets. Tablets come in moisture-protective blisters or bottles, with no cold chain. Ask for a CoA per batch including degradation products, since ACE inhibitor esters can form diketopiperazine impurities, plus the GMP certificate, a CoPP and a nitrosamine risk assessment. It is prescription-only. State strength, pack size and label language.