Clevidipine 0.5 mg/mL Suppliers & Bulk Manufacturers

Available Forms: Injection

Available Strengths: 0.5 mg/mL

Reference Brands: Cleviprex (USA)

Category: Heart Disorder

Clevidipine is a Heart Disorder product available as Injection in strengths 0.5 mg/mL. It corresponds to the reference brand Cleviprex (USA). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Clevidipine, marketed under the trade name Cleviprex, is an intravenous dihydropyridine calcium channel blocker indicated for the rapid reduction of blood pressure when oral therapy is not feasible or desirable. Administered exclusively via IV, clevidipine is titrated by healthcare practitioners to achieve precise blood pressure control. It has an ultra-short half-life of approximately one minute and is rapidly metabolized by blood and tissue esterases, allowing for immediate adjustment of antihypertensive effects.

Clevidipine selectively targets L-type calcium channels in vascular smooth muscle, with minimal effects on myocardial contractility or cardiac conduction. By dilating arterial vessels, it decreases systemic vascular resistance, effectively lowering mean arterial pressure without reducing cardiac filling pressure (preload). This selectivity ensures that myocardial oxygen demand is not increased and coronary blood flow remains stable, minimizing the risk of ischemia.

Due to its rapid onset, short duration, and high vascular selectivity, clevidipine is widely used in perioperative and critical care settings for the management of acute hypertension, hypertensive emergencies, and other situations requiring controlled and reversible blood pressure reduction.