Eflornithine Hydrochloride 13.9% Suppliers & Bulk Manufacturers

Available Forms: Creams

Available Strengths: 13.9%

Reference Brands: Vaniqa (USA/EU)

Category: Derma Drugs

Eflornithine cream is used to reduce unwanted facial hair growth in women by inhibiting an enzyme involved in hair follicle function. The injectable form is used for the treatment of sleeping sickness caused by Trypanosoma brucei gambiense.

Product Description:

Eflornithine irreversibly inhibits ornithine decarboxylase, the rate-limiting enzyme in polyamine synthesis. Polyamines are required for rapid cell division, and in the hair follicle that means the matrix cells that build the hair shaft. Inhibiting the enzyme slows hair growth; it does not remove hair or destroy the follicle, so growth resumes when treatment stops.

It is used to reduce unwanted facial hair in women, applied twice daily at least eight hours apart, to clean dry skin, and not washed off for four hours. It is not a depilatory: patients continue their usual hair removal method and the cream reduces how often it is needed. Improvement takes six to eight weeks, and treatment is stopped if there is no benefit by four months. Local stinging, burning, acne and folliculitis are the common adverse effects. Facial hirsutism warrants investigation for an underlying endocrine cause rather than treatment of the symptom alone.

Sourcing notes. The same molecule is used systemically, at far higher doses, to treat African trypanosomiasis — a completely separate product, market and supply chain. The cream is registered in the US, EU and several other markets; confirm the destination. Tube size matters, since the product is used continuously and cost per month decides adherence.