Diflorasone Diacetate 0.05% Suppliers & Bulk Manufacturers

Available Forms: Cream / Ointment / Gel

Available Strengths: 0.05%

Reference Brands: Florone (USA)

Category: Derma Drugs

Diflorasone is a high-potency topical corticosteroid used to treat inflammatory skin conditions such as eczema, psoriasis, and dermatitis. It helps relieve itching, redness, and swelling by suppressing inflammation and the immune response in the skin.

Product Description:

Diflorasone diacetate is a high-potency topical corticosteroid — US class 1 to 2, European class IV — placing it near the top of the potency ladder. The two fluorine atoms increase glucocorticoid receptor binding and slow metabolism in the skin, producing strong suppression of the inflammatory cascade in the epidermis and upper dermis.

It is used for inflammatory dermatoses that resist weaker steroids: plaque psoriasis, lichen planus, discoid lupus, severe hand eczema and lichen simplex chronicus, applied to trunk, limbs, palms and soles rather than to the face or flexures. Courses are short and defined, usually no more than two to three weeks, with a step down to a weaker steroid afterwards. At this potency the risks are real: skin atrophy and striae that do not fully reverse, telangiectasia, and adrenal suppression when large areas are treated or the preparation is occluded, particularly in children, where it is generally avoided.

Sourcing notes. Cream, ointment and gel are separate registrations, and the ointment is effectively more potent than the cream of the same strength. Off patent, with the originator discontinued in some markets. Quotations should state the potency classification used, since US and European class numbering runs in opposite directions.