Alitretinoin 10 mg, 30 mg, 0.1% Suppliers & Bulk Manufacturers

Available Forms: Capsule / Gel

Available Strengths: 10 mg, 30 mg, 0.1%

Reference Brands: Panretin (USA), Toctino (EU)

Category: Derma Drugs

Alitretinoin 10 mg and 30 mg soft capsules for severe chronic hand eczema and 0.1% gel for Kaposi sarcoma skin lesions, for importers, distributors and hospital pharmacies checking each registration.

Product Description:

Alitretinoin is 9-cis-retinoic acid, a natural vitamin A derivative that binds both retinoic acid receptors and retinoid X receptors and changes how cells grow, differentiate and die. This page covers two quite different products. Soft capsules of 10 mg and 30 mg are taken by mouth for a severe skin disease, and a 0.1% gel is applied to the skin lesions of a tumour. They have separate registrations, users and handling, so buyers should treat them as two distinct items.

Oral capsules are used in adults with severe chronic hand eczema unresponsive to potent topical corticosteroids, once daily with a main meal for 12 to 24 weeks under a dermatologist. Alitretinoin is strongly teratogenic, so women who could become pregnant follow a pregnancy prevention programme, and patients must not donate blood. Headache, raised lipids and thyroid changes are common, and tetracyclines are avoided. The 0.1% gel treats cutaneous lesions of AIDS-related Kaposi sarcoma, applied to lesions only, sparing normal skin.

Sourcing notes. Check registration form by form: the capsules and the gel are authorised in different markets, and one may be unavailable where the other is registered. The capsules come with risk minimisation materials, so ask for the approved educational pack and patient reminder card. Retinoids are light-sensitive: keep capsules in the original blister and the gel in its tube, away from light, with no cold chain. Expect a CTD dossier with stability for your climatic zone. Request a CoA per batch with assay and isomeric impurities, the GMP certificate and a CoPP. Both forms are prescription-only.