Alitretinoin 10 mg, 30 mg, 0.1% Suppliers & Bulk Manufacturers

Available Forms: Capsule / Gel

Available Strengths: 10 mg, 30 mg, 0.1%

Reference Brands: Panretin (USA), Toctino (EU)

Category: Derma Drugs

Alitretinoin is a Derma Drugs product available as Capsule / Gel in strengths 10 mg, 30 mg, 0.1%. It corresponds to the reference brands Panretin (USA), Toctino (EU). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Alitretinoin, also known as 9-cis-retinoic acid, is a naturally occurring derivative of vitamin A and a first-generation retinoid with both oral and topical therapeutic activity. It was developed by Ligand Pharmaceuticals and received regulatory approval in 1999 for medical use. Alitretinoin exhibits antineoplastic and chemopreventive properties and has been used in the management of specific dermatological and oncological conditions.

At the molecular level, alitretinoin binds to and activates both retinoic acid receptors (RAR) and retinoid X receptors (RXR), which function as nuclear transcription factors. Activation of these receptors leads to modulation of gene expression involved in cell growth and differentiation. Through this mechanism, alitretinoin inhibits abnormal cell proliferation, promotes cellular differentiation, and induces apoptosis in both normal and malignant cells.

Alitretinoin is administered orally or topically depending on the indication. Its pharmacological profile supports its use in severe dermatological disorders and selected cancer-related conditions where regulation of cell growth and immune response is required. Due to its retinoid nature, alitretinoin also carries known teratogenic and embryotoxic risks, necessitating careful patient selection and monitoring during therapy.