Efavirenz Suppliers & Bulk Manufacturers

Available Forms: Tablet & Capsule

Available Strengths: Tab: 200 mg, 600 mg; Cap: 50 mg, 100 mg, 200 mg

Reference Brands: Sustiva®(US); Stocrin®(EU)

Category: Anti Viral

Efavirenz 200 mg and 600 mg tablets and 50 mg, 100 mg and 200 mg capsules, an NNRTI antiretroviral for HIV-1, for national HIV programmes, tender buyers, hospitals and distributors.

Product Description:

Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI) active against HIV-1 but not HIV-2. It binds the viral reverse transcriptase and stops it copying viral RNA into DNA. This page lists film-coated tablets at 200 mg and 600 mg and hard capsules at 50 mg, 100 mg and 200 mg. The 600 mg tablet is the adult once-daily dose; smaller strengths allow weight-band dosing in children, and some labels let the capsule be opened onto soft food.

Efavirenz is always combined with other antiretrovirals, often in a fixed-dose tablet with tenofovir and lamivudine or emtricitabine. WHO now prefers dolutegravir-based first-line regimens, and efavirenz has become an alternative option, with a 400 mg dose in some combinations. It is taken on an empty stomach at bedtime, as food raises levels and night dosing eases dizziness and vivid dreams. Psychiatric symptoms, rash, liver enzyme rises and QT prolongation are key precautions, and CYP2B6 and CYP3A4 interactions are many.

Sourcing notes. Efavirenz is a prescription-only antiretroviral bought mainly by national HIV programmes and donor-funded tenders, which usually require WHO prequalification or stringent regulator approval plus a CTD dossier with bioequivalence data. As demand shifts towards dolutegravir regimens, check your strength is still on the tender list before ordering. HDPE bottles, sometimes with desiccant, are typical; ask for stability data at zone IVb conditions. Request a batch CoA, GMP certificate and CoPP. Specify strength, tablet or capsule, count per bottle and labelling language.

Also known as: efavirenz (Spanish, Portuguese, Italian, Turkish, Indonesian, Vietnamese), éfavirenz (French), Efavirenz (German), эфавиренз (Russian), إيفافيرينز (Arabic), 依法韦仑 (Chinese), エファビレンツ (Japanese), 에파비렌즈 (Korean), อีฟาวิเรนซ์ (Thai).