Efavirenz + Emtricitabine + TDF 600/200/300 mg Suppliers & Bulk Manufacturers

Available Forms: Tablet

Available Strengths: 600/200/300 mg

Reference Brands: Atripla(US/EU)

Category: Anti Viral

Efavirenz 600 mg, emtricitabine 200 mg and tenofovir DF 300 mg tablets, a complete once-daily single-tablet HIV regimen. For national HIV programmes, donor-funded tenders, hospitals and licensed importers.

Product Description:

This single tablet holds a complete once-daily HIV regimen: efavirenz 600 mg, a non-nucleoside reverse transcriptase inhibitor, with emtricitabine 200 mg and tenofovir disoproxil fumarate 300 mg, two nucleoside or nucleotide reverse transcriptase inhibitors. The three drugs act on the same viral enzyme at two different sites, making resistance harder to develop. A close relative uses lamivudine in place of emtricitabine; they are not the same product, and tenders specify which they want.

WHO guidelines now prefer dolutegravir-based first-line treatment, with efavirenz kept as an alternative, often at 400 mg, so demand for this 600 mg form has fallen. It is taken once daily on an empty stomach, ideally at bedtime, to ease efavirenz's dizziness, vivid dreams and mood changes. A psychiatric history needs care. Tenofovir DF can harm kidney function and bone density, so creatinine is checked. Efavirenz induces liver enzymes, lowering levels of many drugs including some hormonal contraceptives. Stopping it in hepatitis B co-infection can trigger a flare.

Sourcing notes. Donor-funded and public tenders usually want WHO prequalification or stringent-authority approval; ask for the reference and check that it is current. Confirm patent and licensing status in the destination before quoting. Request a CoA per batch with assay, dissolution and related substances for all three actives, the bioequivalence report, the GMP certificate and a CoPP. The large film-coated tablets are moisture-sensitive and usually packed 30 to an HDPE bottle with desiccant. Zone IVb stability data matter for hot humid markets. State bottle count, quantity and label language.