Brincidofovir 100 mg, 10 mg/ml Suppliers & Bulk Manufacturers

Available Forms: Tablets / Oral suspension

Available Strengths: 100 mg, 10 mg/ml

Reference Brands: Tembexa (USA/EU)

Category: Anti Viral

Brincidofovir is a Anti Viral product available as Tablets / Oral suspension in strengths 100 mg, 10 mg/ml. It corresponds to the reference brand Tembexa (USA/EU). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Brincidofovir is an oral antiviral medication and a lipid-conjugated prodrug of cidofovir designed to improve bioavailability and reduce toxicity compared to intravenous cidofovir. It is composed of cidofovir linked through its phosphonate group to a lipid, 3-hexadecyloxy-1-propanol, which facilitates efficient absorption through the intestinal wall and penetration into virus-infected cells.

Once inside target cells, brincidofovir is cleaved to release cidofovir, which is then phosphorylated by cellular enzymes to form the active metabolite, cidofovir diphosphate. This active form mimics natural nucleotides and competes with deoxycytosine-5-triphosphate (dCTP) for incorporation into viral DNA by viral DNA polymerase. Incorporation of cidofovir diphosphate into the viral DNA disrupts DNA polymerization, halts viral replication, and ultimately inhibits the proliferation of double-stranded DNA viruses.

Compared to traditional cidofovir therapy, brincidofovir offers enhanced oral bioavailability, improved cellular uptake, and reduced systemic toxicity, making it a more convenient and effective option for managing infections caused by a range of DNA viruses.