Etravirine 25 mg, 100 mg, 200 mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 25 mg, 100 mg, 200 mg

Reference Brands: Intelence (USA), Intelence (EU)

Category: Anti Viral

Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with other antiretroviral agents to treat HIV-1 infection. It works by blocking the action of the reverse transcriptase enzyme, thereby preventing the virus from multiplying in the body. Etravirine is typically used in patients who have developed resistance to other NNRTIs.

Product Description:

Etravirine is a second-generation non-nucleoside reverse transcriptase inhibitor. Its design is what distinguishes it: the molecule is flexible and can bind the enzyme's pocket in several conformations, so single mutations that defeat efavirenz and nevirapine do not necessarily defeat it. Several mutations are usually needed before resistance emerges.

It is used with other antiretrovirals for HIV-1 in treatment-experienced adults and in children from two years of age, given twice daily with food — absorption falls substantially on an empty stomach. Rash is the characteristic adverse effect, usually mild and in the first weeks, but severe reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis have occurred and require immediate discontinuation. It both induces and inhibits cytochrome enzymes, so its interaction profile is complicated: it cannot be combined with several other antiretrovirals, and it interacts with rifampicin, carbamazepine and St John's wort.

Sourcing notes. Generic versions exist in some markets. Tablets can be dispersed in water for patients who cannot swallow them, which matters for paediatric use and is worth stating in product information. Demand comes from second- and third-line HIV programmes rather than first-line tenders.