Enfuvirtide Acetate 90 mg/vial Suppliers & Bulk Manufacturers

Available Forms: Injection

Available Strengths: 90 mg/vial

Reference Brands: Fuzeon (USA/EU)

Category: Anti Viral

Enfuvirtide is an antiretroviral drug used in the treatment of HIV-1 infection in combination with other antiretroviral agents. It is a fusion inhibitor that prevents the HIV virus from entering human immune cells by blocking the fusion of the viral and cellular membranes. This helps in controlling viral replication and slowing the progression of the infection.

Product Description:

Enfuvirtide is a 36-amino-acid peptide that copies part of the HIV-1 gp41 envelope protein. When the virus fuses with a cell, gp41 folds on itself to pull the two membranes together; enfuvirtide binds one of the two helical regions and prevents that folding, so the virus cannot enter. It was the first fusion inhibitor and the first antiretroviral to act outside the cell.

It is used in combination therapy for HIV-1 in heavily treatment-experienced patients whose virus is resistant to multiple classes. Because it works at a completely different point in the life cycle, it retains activity against virus resistant to reverse transcriptase and protease inhibitors. Its limitation is practical rather than virological: as a peptide it must be injected subcutaneously twice a day, and injection site reactions — nodules, induration, pain — occur in almost every patient and are the usual reason for stopping. Newer oral agents have reduced its use considerably.

Sourcing notes. Originator product with complex peptide synthesis, supplied as lyophilised powder for reconstitution. Demand is small and specialist, from HIV centres managing multi-drug-resistant disease, and it functions as a salvage option rather than a volume product.