Raltegravir 100mg, 400 mg, 600mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 100mg, 400 mg, 600mg

Reference Brands: Isentress (USA/EU)

Category: Anti Viral

Raltegravir is an HIV-1 integrase strand transfer inhibitor that interferes with the virus’s ability to integrate its genetic material into host cells. It is used as part of combination antiretroviral therapy to lower viral load and improve immune function.

Product Description:

Raltegravir was the first integrase strand transfer inhibitor. HIV must insert its DNA into the host genome to establish infection, and the viral integrase enzyme performs that step; raltegravir binds the enzyme-DNA complex and blocks strand transfer, so the viral DNA is never integrated. Because no human enzyme does this, the class is unusually well tolerated.

It is used with other antiretrovirals for HIV-1 in adults and children from birth, including in pregnancy and in post-exposure prophylaxis, where its rapid viral load reduction is valued. It has few drug interactions because it is metabolised by glucuronidation rather than cytochrome enzymes, which makes it useful in patients on tuberculosis treatment or complex co-medication. Its drawbacks are a lower genetic barrier to resistance than the newer integrase inhibitors, and twice-daily dosing for the standard formulation. Rash and, rarely, severe hypersensitivity occur; creatine kinase rises and myopathy have been reported.

Sourcing notes. Generic versions are available in many markets. Film-coated tablets, chewable tablets and granules for suspension are separate registrations and are not interchangeable milligram for milligram — the chewable and granule forms have higher bioavailability, a documented source of dosing error in children.