Diosmin + Hesperidin 450 mg + 50 mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 450 mg + 50 mg

Reference Brands: Daflon (EU)

Category: Heart Disorder

Diosmin + Hesperidin is a combinational medicine used in the treatment of varicose veins. It improves blood flow in the veins and restores its function.

Product Description:

Diosmin and hesperidin are flavonoids extracted from citrus peel, supplied as a micronised purified fraction in which particle size is reduced to improve absorption. They act on the vein wall and on venous tone rather than on the heart or arteries: they prolong the action of noradrenaline on venous smooth muscle, improve lymphatic drainage, and reduce the adhesion of white cells to the endothelium, which is one of the processes that damages valves in chronic venous disease.

The combination is used for chronic venous insufficiency — the aching, heaviness, swelling and night cramps of varicose veins — and for acute haemorrhoidal episodes, where a short high-dose course is the usual regimen. It relieves symptoms and reduces oedema; it does not remove varicose veins, and compression remains the mainstay. It is well tolerated, with mild gastrointestinal upset the usual complaint. It is generally avoided in the first trimester.

Sourcing notes. Classified as a medicine in France and much of Europe and as a food supplement elsewhere, which changes both the registration route and the claims that may be made. Micronised and non-micronised preparations are not equivalent in absorption, so the specification should state which. Long courses make demand steady and forecastable.