Diflunisal 250 mg, 500 mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 250 mg, 500 mg

Reference Brands: Dolobid (USA/EU)

Category: Analgesic

Diflunisal is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve mild to moderate pain, inflammation, and symptoms of arthritis. It works by inhibiting prostaglandin synthesis, thereby reducing pain, swelling, and joint stiffness.

Product Description:

Diflunisal is a difluorophenyl derivative of salicylic acid. It inhibits COX enzymes like other NSAIDs, but unlike aspirin it is not metabolised to salicylate and it binds platelet COX reversibly, so its antiplatelet effect wears off as the drug clears. Its long half-life, of the order of eight to twelve hours, allows twice-daily dosing.

It is used for mild to moderate pain and for the symptoms of osteoarthritis and rheumatoid arthritis. It has a second, off-label use of interest: because it binds transthyretin and stabilises it, it has been used in transthyretin amyloidosis, where a randomised trial showed slower neurological progression — a cheap alternative where the licensed stabilisers are unaffordable, though NSAID toxicity limits long-term use in patients with cardiac amyloidosis. Standard NSAID risks apply: gastrointestinal bleeding, kidney impairment, fluid retention and cardiovascular risk. It should not be given with aspirin, and it interacts with methotrexate, lithium and anticoagulants.

Sourcing notes. Off patent with a narrow supplier base, discontinued by the originator and unavailable in several markets. Where it is sourced for amyloidosis the indication is off-label, which affects reimbursement and documentation. Confirm registration in the destination country.