Nabumetone Tablet 500 mg, 750 mg, 1000 mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 500 mg, 750 mg, 1000 mg

Reference Brands: Relafen (USA/EU), Relifex (EU/UK), Gambaran

Category: Analgesic

Nabumetone is a non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. It is mainly used for the treatment of pain and inflammation in osteoarthritis and rheumatoid arthritis. Unlike many NSAIDs, it is a prodrug that becomes active in the body, which may reduce stomach irritation compared to some other NSAIDs.

Product Description:

Nabumetone is unusual among NSAIDs in being a prodrug and non-acidic. The parent compound has little COX activity; it is absorbed and converted in the liver to 6-methoxy-2-naphthylacetic acid, which does the work. Two consequences follow. The stomach is not exposed to an acidic NSAID directly, and the active metabolite is somewhat COX-2 preferring. Together these give it a gastrointestinal profile better than most non-selective NSAIDs, which is the main reason to choose it.

It is used for the signs and symptoms of osteoarthritis and rheumatoid arthritis, taken once daily thanks to a long half-life. The relative gastrointestinal advantage does not remove NSAID risk: bleeding and ulceration still occur, and the cardiovascular, renal and blood pressure cautions of the class apply unchanged, rising with dose and duration. Because activation depends on the liver, exposure rises in hepatic impairment and the dose is reduced.

Sourcing notes. Off patent, with generics in the US, Europe and many other markets. Tablets are large, which matters for patients who struggle to swallow them. Its position is as a better-tolerated alternative for patients who need long-term NSAID therapy, which is what a buyer is usually sourcing it for.