Difelikefalin Acetate 0.5 mg/mL , 1 mg/mL Suppliers & Bulk Manufacturers

Available Forms: Injection

Available Strengths: 0.5 mg/mL , 1 mg/mL

Reference Brands: Korsuva (USA)

Category: Critical Care

Difelikefalin Acetate is a Critical Care product available as Injection in strengths 0.5 mg/mL , 1 mg/mL. It corresponds to the reference brand Korsuva (USA). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Difelikefalin, marketed under the brand name Korsuva, is a peripherally acting opioid peptide used for the treatment of moderate to severe pruritus (itch) associated with chronic kidney disease in patients undergoing hemodialysis. It is a highly selective agonist of the κ-opioid receptor (KOR) that acts predominantly outside the central nervous system, minimizing typical opioid-related side effects.

The mechanism of action of difelikefalin involves dual pathways. By activating KORs on peripheral nerve terminals, it inhibits ion channels responsible for transmitting pain and itch signals, reducing the perception of discomfort. Additionally, it activates KORs expressed by certain immune cells, leading to decreased release of proinflammatory and nerve-sensitizing mediators such as prostaglandins. This combined action helps alleviate itch while addressing the underlying inflammatory component.

Difelikefalin is administered as an intravenous injection during hemodialysis sessions under specialist supervision. Its peripherally restricted activity, targeted mechanism, and favorable safety profile make it a valuable therapeutic option for improving quality of life in patients with chronic kidney disease-associated pruritus, especially in populations where conventional therapies may be less effective or poorly tolerated.