Probenecid Suppliers & Bulk Manufacturers
Available Forms: Tablets
Available Strengths: 500 mg
Reference Brands: Benemid (USA)
Category:
Nephrology
Probenecid is available in Tablets
and strengths such as 500 mg.
Sourced from GMP-certified and ISO-compliant manufacturers, this API meets
global pharmacopeia standards (USP/EP/JP as applicable). Ideal for pharmaceutical
formulation and commercial manufacturing, Probenecid is supplied in
bulk quantities with complete regulatory support including DMF, COA, and MSDS.
|
Technical Specifications & Supply Details
|
| Lead Time |
7 to 60 days (depending on batch size & schedule) |
| MOQ |
As per manufacturer’s batch size |
| COA |
Available with every batch |
| Regulatory Dossier / DMF |
Available upon request |
| Export Documentation |
FSC, COA, Manufacturing License, Product Permission |
| Standards |
IP, BP, USP |
| Certifications |
WHO-GMP, EU-GMP, USFDA (as applicable) |
Probenecid can be exported to over 30 countries across Asia, Africa, Europe,
and Latin America. Flexible packaging, competitive pricing, and a verified supplier
network make Pharmatradz a trusted sourcing partner for pharmaceutical companies
and contract manufacturers worldwide.
Product Description:
Probenecid is a well-established uricosuric medication used primarily in the management of gout and hyperuricemia. It works by increasing the renal excretion of uric acid, thereby lowering elevated serum uric acid levels and helping to prevent gout attacks. Probenecid is particularly effective in patients with chronic gout who under-excrete uric acid and is commonly used as a long-term urate-lowering therapy when other options are unsuitable or insufficient.
In addition to its role in gout management, probenecid has an important pharmacokinetic application in clinical practice. It inhibits renal tubular secretion of several drugs, which can increase and prolong the plasma concentrations of certain antibiotics, including penicillins and cephalosporins. This property allows for optimized antibiotic dosing in specific situations. Probenecid is also used to reduce renal toxicity associated with cidofovir by limiting its uptake into renal tubular cells, thereby offering protective benefits to kidney function.
Clinical evidence further supports the use of probenecid in combination with antibiotics such as cefazolin, where co-administration can allow effective once-daily intravenous dosing instead of multiple daily doses. Overall, probenecid remains a valuable and versatile agent in both metabolic and infectious disease management, with a well-defined mechanism of action and long history of clinical use.
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