Probenecid 500 mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 500 mg

Reference Brands: Benemid (USA)

Category: Nephrology

Probenecid is a Nephrology product available as Tablets in strengths 500 mg. It corresponds to the reference brand Benemid (USA). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Probenecid is a well-established uricosuric medication used primarily in the management of gout and hyperuricemia. It works by increasing the renal excretion of uric acid, thereby lowering elevated serum uric acid levels and helping to prevent gout attacks. Probenecid is particularly effective in patients with chronic gout who under-excrete uric acid and is commonly used as a long-term urate-lowering therapy when other options are unsuitable or insufficient.

In addition to its role in gout management, probenecid has an important pharmacokinetic application in clinical practice. It inhibits renal tubular secretion of several drugs, which can increase and prolong the plasma concentrations of certain antibiotics, including penicillins and cephalosporins. This property allows for optimized antibiotic dosing in specific situations. Probenecid is also used to reduce renal toxicity associated with cidofovir by limiting its uptake into renal tubular cells, thereby offering protective benefits to kidney function.

Clinical evidence further supports the use of probenecid in combination with antibiotics such as cefazolin, where co-administration can allow effective once-daily intravenous dosing instead of multiple daily doses. Overall, probenecid remains a valuable and versatile agent in both metabolic and infectious disease management, with a well-defined mechanism of action and long history of clinical use.