Cyproheptadine 4 mg Suppliers & Bulk Manufacturers

Available Forms: Tablet

Available Strengths: 4 mg

Reference Brands: Periactin®(US & EU)

Category: Allergy Medication

Cyproheptadine 4 mg tablets, a sedating first-generation antihistamine with anti-serotonin action, used for allergic conditions. For importers, pharmacy distributors and hospital buyers.

Product Description:

Cyproheptadine is a first-generation antihistamine of the piperidine group. Besides blocking histamine H1 receptors, it blocks serotonin (5-HT2) receptors and has anticholinergic and sedating effects. That mix sets it apart from newer antihistamines. This page covers 4 mg tablets, the standard strength. The scored tablet allows half doses for children, and tablets keep well, which suits pharmacies and clinics in warm climates.

Labelled uses include allergic rhinitis, allergic conjunctivitis, urticaria and itchy skin conditions. Doctors also use it outside the licence in some settings, for example in serotonin syndrome because of its anti-serotonin action. Doses are usually split through the day. Drowsiness is common, so patients should not drive or drink alcohol until they know how it affects them. Pharmacists will check for angle-closure glaucoma, urinary retention, prostate enlargement and peptic ulcer with obstruction. It should not be used in newborns or premature infants, or with MAO inhibitors, and older adults are more sensitive to its sedative and anticholinergic effects.

Sourcing notes. Cyproheptadine tablets are prescription-only in many countries, though legal status varies. Request a CTD or ACTD dossier with bioequivalence or comparative dissolution data, and Zone IVb stability data for hot, humid regions. Blister packs in PVC/PVDC or alu-alu, or HDPE bottles, are common; store below 30 °C in a dry place. Ask for a CoA on each batch, the site GMP certificate and a CoPP. Your enquiry should give strength, pack size, whether you need a scored tablet and the country of registration.