Cinnarizine & Dimenhydrinate Tablets (20mg + 40mg) Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: (20mg + 40mg)

Reference Brands:

Category: Antipsychotropic Drugs

Cinnarizine+Dimenhydrinate is used in the treatment of vertigo. Cinnarizine + Dimenhydrinate is a combination of two medicines: Cinnarizine and Dimenhydrinate. Cinnarizine is a calcium channel antagonist which works by preventing constriction of the blood vessels of the inner ear. This improves the microcirculation of the ear.

Product Description:

This tablet combines cinnarizine, a calcium channel blocker with antihistamine activity, and dimenhydrinate, an antihistamine long used for motion sickness. Cinnarizine acts mainly on the inner ear, reducing the excitability of the vestibular sensory cells and damping the abnormal signals that cause vertigo. Dimenhydrinate acts centrally at the vomiting centre and vestibular nuclei. Using two agents at reduced doses is intended to give a stronger effect on vertigo with less sedation than a full dose of either alone.

It is used for vertigo of various causes, including vestibular disorders and Ménière's disease, and trials in Germany, where the combination originates, support it against single agents. Both components are sedating, so drowsiness is the main adverse effect and driving is affected. Cinnarizine can cause extrapyramidal symptoms and parkinsonism with long-term use, particularly in older patients, which is a reason to limit treatment duration. Dimenhydrinate adds anticholinergic effects: dry mouth, blurred vision and urinary retention.

Sourcing notes. A fixed-dose combination registered in Germany, parts of Europe, and several Asian and Middle Eastern markets, but not in the US or UK. Confirm the destination market registers the combination rather than the single agents.