Cefpodoxime Proxetil Tablets 50 mg, 100 mg, 200 mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 50 mg, 100 mg, 200 mg

Reference Brands: Vantin (US), Orelox (EU)

Category: Antibiotics

Cefpodoxime proxetil 50 mg, 100 mg and 200 mg tablets, an oral third-generation cephalosporin for respiratory, urinary and skin infections, for importers, distributors and pharmacy wholesalers.

Product Description:

Cefpodoxime proxetil is an oral third-generation cephalosporin. Gut-wall enzymes remove the proxetil ester to release cefpodoxime, which binds penicillin-binding proteins and blocks bacterial cell wall synthesis. It resists many common beta-lactamases and covers streptococci, Haemophilus influenzae, Moraxella catarrhalis and many E. coli and Klebsiella strains, but not Pseudomonas, enterococci or MRSA. This page covers 100 mg and 200 mg film-coated tablets, plus 50 mg, a dispersible tablet for children in some markets.

It is used for sinusitis, pharyngitis, tonsillitis, otitis media and community-acquired pneumonia, and for uncomplicated urinary and skin infections, often as oral step-down after an injectable cephalosporin. Tablets are taken with food. Antacids, H2 blockers and proton pump inhibitors cut absorption by raising gastric pH. Doses are adjusted in severe renal impairment. Pharmacists check for beta-lactam allergy and watch for Clostridioides difficile diarrhoea, and use should follow local resistance data and stewardship rules.

Sourcing notes. Cefpodoxime proxetil is a prescription-only antibiotic, and cephalosporins need dedicated, segregated production areas, so ask the supplier to confirm this in its GMP papers. Request the CTD or ACTD dossier with bioequivalence and zone IVb stability for hot, humid markets. The ester is moisture-sensitive, so prefer aluminium-aluminium blisters. Ask for a batch CoA covering assay, water and impurities, the GMP certificate and a CoPP. In the enquiry, state strength, film-coated or dispersible, pack size and label language.