Tranylcypromine Tablets 10 mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 10 mg

Reference Brands: Parnate® (US & EU)

Category: Antipsychotropic Drugs

Tranylcypromine 10 mg tablets, an irreversible MAOI antidepressant for treatment-resistant major depression, for importers, distributors and hospital pharmacies serving psychiatric services.

Product Description:

Tranylcypromine is a monoamine oxidase inhibitor (MAOI) antidepressant. It blocks both MAO-A and MAO-B irreversibly, slowing the breakdown of serotonin, noradrenaline and dopamine so their brain levels rise. The block lasts until new enzyme is made, about two weeks, so effects outlast the drug. It is chemically related to amphetamine and has some stimulant activity at higher doses. This page covers 10 mg film-coated tablets, the standard strength, given in divided doses built up gradually.

It is a specialist option for major depression that has not responded to other antidepressants, prescribed mainly by psychiatrists. The key hazard is hypertensive crisis. Tyramine-rich foods, such as aged cheese, salami, fermented soy, yeast extracts and tap beer, are avoided during treatment and for two weeks after. Decongestants, other antidepressants, pethidine, tramadol, linezolid, triptans and dextromethorphan can provoke hypertensive or serotonin reactions, and switching needs a washout. Insomnia and postural hypotension are common.

Sourcing notes. Tranylcypromine is prescription-only and is not on the international drug control schedules, but fewer countries register it than newer antidepressants, so check local status before quoting. Ask for the CTD or ACTD dossier with bioequivalence, a batch CoA with assay and impurity results, the GMP certificate and a CoPP. Tablets are kept at room temperature, protected from moisture, with zone IVb stability for hot, humid markets. Ask about minimum order and lead time, and whether the leaflet needs a local tyramine food list.