Pioglitazone Hydrochloride bulk supplier for pharma manufacturers

Pioglitazone Hydrochloride 15 mg, 30 mg, 45 mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 15 mg, 30 mg, 45 mg

Reference Brands: Actos (USA)

Category: Diabetes

Pioglitazone Hydrochloride is a Diabetes product available as Tablets in strengths 15 mg, 30 mg, 45 mg. It corresponds to the reference brand Actos (USA). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

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Product Description:

Pioglitazone is a thiazolidinedione and a PPAR-gamma agonist. It acts in adipose tissue, muscle and liver to increase insulin sensitivity by altering transcription of genes governing glucose and lipid metabolism — which is why the effect builds over weeks rather than days, unlike a secretagogue. It does not stimulate insulin secretion and so carries no intrinsic hypoglycaemia risk when used alone.

The safety profile is what has shaped its use. Fluid retention can precipitate or worsen heart failure and carries a boxed warning; it is contraindicated in NYHA class III and IV. Weight gain is expected. Distal fracture risk is raised, particularly in women. A bladder cancer signal has been examined repeatedly with inconsistent results and remains a labelled caution in most markets.

Sourcing notes. Long off patent, manufactured widely and competitive on price, with 15, 30 and 45 mg all standard strengths and conventional immediate-release tablet manufacture. Supply is rarely the constraint here — market access is. Several regulators restricted or withdrew pioglitazone during the bladder cancer reviews and the positions taken diverged, so formulary status differs more between countries than it does for most drugs of this age. Confirm current registration and any labelled restriction in the destination market before committing to volume.

Pioglitazone Hydrochloride — third party manufacturing & bulk supply

Pioglitazone Hydrochloride 15 mg, 30 mg, 45 mg is available through PharmaTradz for wholesale and bulk supply as well as on a third party (contract) manufacturing basis. Buyers sourcing this product generally take one of three routes:

Wholesale / bulk supply Stock or scheduled supply from an existing manufacturer. The fastest route where the product is already registered in your market.

Third party manufacturing Manufactured to your specification and packed under your own brand and label — suits distributors and brand owners building a portfolio in their market.

Dossier licensing Where a CTD, EU-CTD or ACTD dossier exists it can often be licensed for filing in your name, compressing market entry from years to months.

Indicative minimum order quantity

Pioglitazone Hydrochloride is supplied as Tablets — an oral solid dosage form, so the indicative MOQ is 200,000 units. Actual MOQ is confirmed by the allocated manufacturer against your pack presentation and destination market. See full supply terms for dossier formats, market availability and shelf life.

Manufacturers of Pioglitazone Hydrochloride listed on PharmaTradz hold site-level approvals across WHO-GMP, EU-GMP, USFDA, ANVISA and TGA, verified at onboarding.

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Frequently Asked Questions

Pioglitazone Hydrochloride is used as an oral antidiabetic medication to improve glycemic control in adults with type 2 diabetes mellitus, either alone or in combination with other antidiabetic agents such as metformin, sulfonylureas, or insulin. It is taken together with diet and exercise to help lower blood glucose levels.

Pioglitazone Hydrochloride is the hydrochloride salt of pioglitazone, a thiazolidinedione (TZD) class compound that activates peroxisome proliferator‑activated receptor gamma (PPAR‑γ) to enhance insulin sensitivity in peripheral tissues and liver.

Common trade names for Pioglitazone Hydrochloride include Actos®, and in some regions products are marketed as Glustin®, Glizone®, or Pioz® among others.

Pioglitazone Hydrochloride is manufactured by multiple pharmaceutical companies globally, including the originator Takeda Pharmaceuticals for Actos® and various generic manufacturers.

The generic name is Pioglitazone Hydrochloride.

Brand names include Actos®, Glustin®, Glizone®, Pioz®, and other regional brands depending on the manufacturer and market.

Pioglitazone Hydrochloride is manufactured in various countries including the USA, EU, India, and other regions by different pharmaceutical companies that produce both branded and generic versions.