Metyrosine 250 mg Suppliers & Bulk Manufacturers
Available Forms: Capsules
Available Strengths: 250 mg
Reference Brands: Demser (USA/EU)
Category: Neurology
Metyrosine is a Neurology product available as Capsules in strengths 250 mg. It corresponds to the reference brand Demser (USA/EU). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.
Product Description:
Metyrosine is a methylated tyrosine derivative that acts as a catecholamine synthesis antagonist with antihypertensive properties. It functions by selectively and competitively inhibiting the enzyme tyrosine 3-monooxygenase (tyrosine hydroxylase), which catalyzes the conversion of tyrosine to dihydroxyphenylalanine (DOPA), a key intermediate in the production of catecholamines, including dopamine, norepinephrine, and epinephrine.
By reducing catecholamine synthesis, metyrosine helps manage the elevated hormone levels commonly seen in patients with pheochromocytoma, a rare tumor of the adrenal glands. This decrease in catecholamines contributes to improved control of hypertension and associated cardiovascular symptoms.
Metyrosine is administered orally in capsule form and is primarily used as a preoperative adjunct to stabilize patients before surgical removal of pheochromocytoma. It is also employed in patients with inoperable or malignant tumors to help manage excessive catecholamine-mediated symptoms. By targeting the root cause of catecholamine overproduction, metyrosine provides a pharmacologic option for symptom control in this endocrine disorder.
Metyrosine — third party manufacturing & bulk supply
Metyrosine 250 mg is available through PharmaTradz for wholesale and bulk supply as well as on a third party (contract) manufacturing basis. Buyers sourcing this product generally take one of three routes:
What to include when you enquire
- Destination market — determines which manufacturers hold the right site-level approvals
- First order quantity and estimated annual volume
- Whether you need a registration dossier or the product is already registered
- Packaging, labelling and language requirements
- Incoterms and required shelf life
Manufacturers of Metyrosine listed on PharmaTradz hold site-level approvals across WHO-GMP, EU-GMP, USFDA, ANVISA and TGA, verified at onboarding. Narcotic drugs and controlled substances are supplied strictly against valid import and export permits issued by the competent authorities.
Request a quote for Metyrosine →The Trade Mark owner has been correctly identified under the heading Manufacturer / TM Owner as required by the Act.
Frequently Asked Questions
Metyrosine is used in the management of pheochromocytoma to control excessive catecholamine production. It is indicated as a preoperative adjunct to reduce hypertension and related symptoms and is also used in patients with inoperable or malignant pheochromocytoma.
Metyrosine is a synthetic amino acid derivative that acts as a selective inhibitor of the enzyme tyrosine hydroxylase, which is involved in the synthesis of catecholamines.
The trade name of metyrosine is Demser.
Metyrosine is manufactured and marketed by companies authorized to produce Demser under regulatory approval, originally by Bristol-Myers Squibb.
The generic name of the drug is metyrosine.
The brand name of metyrosine is Demser.
Metyrosine is manufactured under the specifications of its marketing authorization holders in compliance with international pharmaceutical manufacturing standards.
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