Metyrosine Suppliers & Bulk Manufacturers
Available Forms: Capsules
Available Strengths: 250 mg
Reference Brands: Demser (USA/EU)
Category:
Neurology
Product Description:
Metyrosine is a methylated tyrosine derivative that acts as a catecholamine synthesis antagonist with antihypertensive properties. It functions by selectively and competitively inhibiting the enzyme tyrosine 3-monooxygenase (tyrosine hydroxylase), which catalyzes the conversion of tyrosine to dihydroxyphenylalanine (DOPA), a key intermediate in the production of catecholamines, including dopamine, norepinephrine, and epinephrine.
By reducing catecholamine synthesis, metyrosine helps manage the elevated hormone levels commonly seen in patients with pheochromocytoma, a rare tumor of the adrenal glands. This decrease in catecholamines contributes to improved control of hypertension and associated cardiovascular symptoms.
Metyrosine is administered orally in capsule form and is primarily used as a preoperative adjunct to stabilize patients before surgical removal of pheochromocytoma. It is also employed in patients with inoperable or malignant tumors to help manage excessive catecholamine-mediated symptoms. By targeting the root cause of catecholamine overproduction, metyrosine provides a pharmacologic option for symptom control in this endocrine disorder.
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