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Neostigmine Methylsulfate bulk supplier for pharma manufacturers

Neostigmine Methylsulfate Suppliers & Bulk Manufacturers

Available Forms: Injection

Available Strengths: 0.5 mg/mL, 1 mg/ml

Reference Brands: Prostigmin (USA), Neostigmine (USA)

Category: Neurology

Neostigmine Methylsulfate is available in Injection and strengths such as 0.5 mg/mL, 1 mg/ml. Sourced from GMP-certified and ISO-compliant manufacturers, this API meets global pharmacopeia standards (USP/EP/JP as applicable). Ideal for pharmaceutical formulation and commercial manufacturing, Neostigmine Methylsulfate is supplied in bulk quantities with complete regulatory support including DMF, COA, and MSDS.

Technical Specifications & Supply Details
Lead Time 7 to 60 days (depending on batch size & schedule)
MOQ As per manufacturer’s batch size
COA Available with every batch
Regulatory Dossier / DMF Available upon request
Export Documentation FSC, COA, Manufacturing License, Product Permission
Standards IP, BP, USP
Certifications WHO-GMP, EU-GMP, USFDA (as applicable)

Neostigmine Methylsulfate can be exported to over 30 countries across Asia, Africa, Europe, and Latin America. Flexible packaging, competitive pricing, and a verified supplier network make Pharmatradz a trusted sourcing partner for pharmaceutical companies and contract manufacturers worldwide.

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📘 Sourcing Guide

Product Description:

Neostigmine is a medication used to improve neuromuscular function and manage specific medical conditions, marketed under the brand name Bloxiverz and other regional brands. It is commonly used to treat myasthenia gravis, a chronic autoimmune disorder that causes muscle weakness, as well as Ogilvie syndrome, and urinary retention when there is no physical blockage. Additionally, neostigmine is used in anesthesia to reverse the effects of non-depolarizing neuromuscular blocking agents after surgery, helping restore normal muscle function.

Neostigmine works as a reversible cholinesterase inhibitor, increasing the concentration of acetylcholine at the neuromuscular junction. This enhances communication between nerves and muscles, improving muscle contraction and strength. The medication is administered via injection into a vein, muscle, or under the skin, with effects typically appearing within 30 minutes and lasting up to 4 hours.

Neostigmine provides a safe and effective option for clinicians to manage neuromuscular disorders, improve postoperative recovery, and address complications like urinary retention. Its rapid onset and predictable duration make it suitable for both acute interventions and ongoing management under careful medical supervision.

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Frequently Asked Questions


Neostigmine methylsulfate is used to improve neuromuscular transmission in patients with myasthenia gravis and other conditions causing muscle weakness. It is also used to reverse the effects of non-depolarizing neuromuscular blockers after surgery.


Neostigmine methylsulfate is a synthetic reversible cholinesterase inhibitor. It is chemically manufactured and is not derived from natural or biological sources.


Neostigmine methylsulfate is marketed under trade names such as Prostigmin and Neostigmine Methylsulfate Injection.


Neostigmine methylsulfate is manufactured and commercialized by multiple pharmaceutical companies, including Pfizer (Prostigmin) and other authorized generic manufacturers, following US FDA and EU GMP regulations.


The generic name is neostigmine methylsulfate.


The brand names include Prostigmin and Neostigmine Methylsulfate Injection.


Neostigmine methylsulfate is manufactured in facilities compliant with US FDA and EU GMP standards, including production sites in the USA, Europe, and other regulated markets.

Yes, Neostigmine Methylsulfate is available with DMF and other regulatory documents such as COA and MSDS. These can be provided upon request for qualified buyers.

Absolutely. Sample requests are accepted for formulation trials and quality checks. Please submit an enquiry to initiate the process.

Our manufacturing partners are GMP-certified and comply with ISO and WHO standards, ensuring global quality benchmarks.

Lead times vary based on quantity and destination, but most orders are fulfilled within 1–3 weeks. Express shipping options are available.

Yes, Neostigmine Methylsulfate is exported to over 30 countries across Asia, Africa, Europe, and Latin America. We support documentation for customs and regulatory clearance.

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