Entacapone bulk supplier for pharma manufacturers

Entacapone 200mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 200mg

Reference Brands: COMTAN (USA/EU)

Category: Neurology

Entacapone is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT), an enzyme involved in dopamine breakdown. It is used as an adjunct to levodopa/carbidopa therapy in patients with Parkinson’s disease to prolong the effect of levodopa and improve motor control. The medicine is taken orally, usually with each levodopa dose. Its common brand name is Comtan, available as 200 mg film-coated tablets worldwide.

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Product Description:

Entacapone is a peripherally acting inhibitor of catechol-O-methyltransferase. When dopa decarboxylase is already blocked by carbidopa or benserazide, COMT becomes the main peripheral route for breaking down levodopa. Inhibiting it lengthens levodopa's plasma half-life and raises the amount reaching the brain, which reduces end-of-dose "wearing off" in Parkinson's disease and adds on-time.

It has no effect on its own. Each 200 mg tablet is taken with every levodopa dose, up to about eight a day, and the levodopa dose often needs reducing within days because dopaminergic effects — dyskinesia, nausea, hallucinations — increase. Harmless reddish-brown discolouration of urine is common and worth warning patients about. Diarrhoea is the most common reason for stopping. Unlike tolcapone it has not been associated with hepatotoxicity, so it needs no liver monitoring.

Sourcing notes. Generic and inexpensive. A large share of volume is the fixed-dose triple combination with levodopa and carbidopa, which is a separate product and cannot be substituted by co-prescribing single tablets without changing the dosing schedule. Single-entity entacapone tablets are film-coated and conventionally manufactured. Newer once-daily COMT inhibitors compete in some markets, but entacapone remains the reference product and what tender programmes specify.

Entacapone — third party manufacturing & bulk supply

Entacapone 200mg is available through PharmaTradz for wholesale and bulk supply as well as on a third party (contract) manufacturing basis. Buyers sourcing this product generally take one of three routes:

Wholesale / bulk supply Stock or scheduled supply from an existing manufacturer. The fastest route where the product is already registered in your market.

Third party manufacturing Manufactured to your specification and packed under your own brand and label — suits distributors and brand owners building a portfolio in their market.

Dossier licensing Where a CTD, EU-CTD or ACTD dossier exists it can often be licensed for filing in your name, compressing market entry from years to months.

Indicative minimum order quantity

Entacapone is supplied as Tablets — an oral solid dosage form, so the indicative MOQ is 200,000 units. Actual MOQ is confirmed by the allocated manufacturer against your pack presentation and destination market. See full supply terms for dossier formats, market availability and shelf life.

Manufacturers of Entacapone listed on PharmaTradz hold site-level approvals across WHO-GMP, EU-GMP, USFDA, ANVISA and TGA, verified at onboarding.

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Frequently Asked Questions

Entacapone is used in the treatment of Parkinson’s disease. It is given along with levodopa and carbidopa to help improve and prolong the effects of levodopa by preventing its breakdown in the body. This helps reduce symptoms such as stiffness, tremors, and movement difficulties in patients with Parkinson’s disease.

Entacapone is made from Entacapone, a selective and reversible inhibitor of the enzyme catechol-O-methyltransferase (COMT), which helps increase and maintain dopamine levels in the brain.

The common trade names of Entacapone include Comtan and Stalevo (a combination of carbidopa, levodopa, and entacapone).

Entacapone (Comtan) is manufactured by Novartis Pharmaceuticals and marketed globally by Orion Corporation and other licensed companies.

The generic name of Entacapone is Entacapone.

The brand names of Entacapone are Comtan and Stalevo.

Entacapone is manufactured in Finland by Orion Corporation and in several other countries under license by Novartis and approved pharmaceutical manufacturers.