Eletriptan Hydrobromide 20mg, 40mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 20mg, 40mg

Reference Brands: Relpax (USA/EU)

Category: Neurology

Eletriptan hydrobromide is a selective serotonin (5-HT1B/1D) receptor agonist used for the acute treatment of migraine attacks with or without aura. It works by narrowing dilated blood vessels in the brain and reducing substances that trigger headache pain, nausea, and sensitivity to light and sound.

Product Description:

Eletriptan is a lipophilic 5-HT1B/1D agonist, and in head-to-head trials the 40 mg dose is among the most effective oral triptans for pain relief at two hours and for sustained freedom from pain. Higher lipophilicity gives better central penetration and oral bioavailability of about fifty percent, well above sumatriptan. It is taken at the onset of headache pain, with one repeat permitted after two hours if the headache returns.

Unlike most triptans it is extensively metabolised by CYP3A4, which creates the key interaction: it must not be used within seventy-two hours of strong CYP3A4 inhibitors such as ketoconazole, itraconazole, clarithromycin or ritonavir. Class contraindications apply — ischaemic heart disease, cerebrovascular disease, uncontrolled hypertension and hemiplegic or basilar migraine. The 80 mg dose is licensed in some markets but adds adverse effects more than benefit.

Sourcing notes. Off patent, with generics in the US and Europe, so commodity pricing applies. The hydrobromide salt is standard and the active has several polymorphic forms; the form in the reference product must be matched and controlled, since polymorph conversion affects dissolution. Tablets are film-coated, with the coating partly masking a bitter taste. Registration rather than manufacture limits availability in markets where only sumatriptan is registered.