Benztropine Mesylate 0.5 mg, 1 mg, 2 mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 0.5 mg, 1 mg, 2 mg

Reference Brands: Cogentin (USA)

Category: Neurology

Benztropine (also known as Benztropine mesylate) is an anticholinergic and antihistaminic agent used primarily to treat symptoms of Parkinson’s disease and to control movement disorders (such as tremors, stiffness, or dystonia) caused by certain psychiatric medications, especially antipsychotics.

Product Description:

Benztropine is a centrally acting anticholinergic with antihistamine activity, structurally a hybrid of atropine and diphenhydramine. Its main use today is not idiopathic Parkinson's disease but drug-induced extrapyramidal symptoms — acute dystonia, parkinsonism and akathisia caused by antipsychotics — where restoring the dopamine-acetylcholine balance in the striatum relieves rigidity and tremor quickly.

It is not effective against tardive dyskinesia and may worsen it, which is a common prescribing error. Anticholinergic burden is the limiting concern: dry mouth, constipation, urinary retention, blurred vision and, in older patients, confusion and cognitive decline. It appears on the Beers list of drugs to avoid in older adults, and it impairs sweating, so heat stroke is a real risk in hot climates or with strenuous work.

Sourcing notes. Long off patent and inexpensive. Registration is concentrated in the US and a few other markets; much of Europe and South Asia uses trihexyphenidyl or procyclidine for the same indication instead, so a buyer asking for benztropine should confirm it is registered in the destination market rather than assuming it is. Demand tracks antipsychotic prescribing, which makes psychiatric hospitals and mental-health tender programmes the usual buyers. Tablets are simple immediate-release manufacture; the injection is a separate product with separate registration.