Methylergonovine Maleate 0.2 mg, 0.2 mg/mL Suppliers & Bulk Manufacturers

Available Forms: Tablet / Injection

Available Strengths: 0.2 mg, 0.2 mg/mL

Reference Brands: Methergine (USA)

Category: Women's Health

Methylergonovine is a semisynthetic ergot alkaloid that acts as a strong uterotonic — it stimulates uterine muscle contraction to reduce bleeding after childbirth. It is used by obstetricians and in maternity care settings to prevent or treat postpartum hemorrhage. Common effects may include increased blood pressure, nausea, headache, and uterine cramps; monitoring is important during use.

Product Description:

Methylergonovine is a semisynthetic ergot alkaloid that causes strong, sustained contraction of uterine smooth muscle through effects on alpha-adrenergic and serotonin receptors. Unlike oxytocin, which produces rhythmic contractions, it produces tetanic contraction — the uterus clamps down and stays down, compressing the vessels at the placental bed.

It is used to prevent and treat postpartum haemorrhage from uterine atony, usually as a second-line agent after oxytocin, and to manage subinvolution of the uterus. Postpartum haemorrhage remains a leading cause of maternal death worldwide, and having more than one uterotonic available matters. Because it constricts blood vessels generally, it raises blood pressure and is contraindicated in hypertension, pre-eclampsia and eclampsia — precisely the patients who often bleed — so drug choice depends on the clinical picture. It must not be given before delivery of the placenta or with a retained second twin.

Sourcing notes. The injection is heat and light sensitive, and degraded ergometrine-type uterotonics have been a documented quality problem in hot-climate supply chains; refrigerated, light-protected storage and transport are required, and stability data should reflect the destination climate zone. Maternity units and public programmes are the buyers.