Methazolamide 25 mg, 50 mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 25 mg, 50 mg

Reference Brands: Generic formulations marketed under different names

Category: Opthalmology

Methazolamide is a carbonic‑anhydrase inhibitor that lowers intra‑ocular pressure by reducing fluid production in the eye. It is used to treat glaucoma (chronic open‑angle glaucoma, secondary glaucoma, and to reduce pressure temporarily in acute angle‑closure glaucoma).

Product Description:

Methazolamide is an oral carbonic anhydrase inhibitor — a tablet, not a drop. Inhibiting carbonic anhydrase in the ciliary body reduces aqueous humour production and lowers intraocular pressure. It is a close relative of acetazolamide, and the differences between them are practical: methazolamide is less protein-bound, penetrates the eye better, has a longer half-life allowing twice or three times daily dosing, and is excreted less by the kidney, so it causes fewer kidney stones and less renal impairment.

It is used for glaucoma when topical treatment is insufficient, and in acute angle-closure glaucoma to bring pressure down quickly before definitive treatment. Systemic carbonic anhydrase inhibition has real costs: metabolic acidosis, tingling of the hands, feet and face, fatigue, appetite loss, taste disturbance and, with time, depression. These limit long-term use, so it is generally a bridge to laser or surgery rather than maintenance therapy. It is a sulfonamide, with the rare but serious risks of that class, including Stevens-Johnson syndrome and aplastic anaemia.

Sourcing notes. Off patent with a narrow supplier base and a history of shortage. Buyers should note this is a systemic tablet: it is dispensed through pharmacy, not through ophthalmic surgical supply.