Linaclotide bulk supplier for pharma manufacturers

Linaclotide 72 mcg, 145 mcg, 290 mcg Suppliers & Bulk Manufacturers

Available Forms: Capsules

Available Strengths: 72 mcg, 145 mcg, 290 mcg

Reference Brands: Linzess (USA), Constella (EU)

Linaclotide is used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC). It works by increasing fluid secretion in the intestines, helping ease bowel movements and reduce abdominal discomfort. It is taken orally once daily.

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Product Description:

Linaclotide is a fourteen-amino-acid peptide agonist of guanylate cyclase-C on the luminal surface of intestinal epithelium. Activation raises cyclic GMP inside the cells, which opens the CFTR chloride channel and draws chloride, bicarbonate and water into the gut lumen, speeding transit and softening stool. Cyclic GMP released from the cells also reduces the firing of pain-sensing nerves, so it relieves abdominal pain as well as constipation. It acts locally and is barely absorbed.

It is used for irritable bowel syndrome with constipation and chronic idiopathic constipation in adults, and in the US for functional constipation in children aged six and over. It is taken once daily at least thirty minutes before the first meal. Diarrhoea is the main adverse effect and the main reason patients stop. It is contraindicated in children under two because of dehydration deaths in juvenile animal studies.

Sourcing notes. Linaclotide remains protected in major markets, with generic entry timing set by patents and settlements that differ by country. Confirm the exclusivity position before quoting. As a peptide it is made by synthesis and needs moisture protection — capsules are packed with desiccant, and pharmacy repackaging into dose-administration aids is discouraged. The three strengths are for different indications and age groups.

Linaclotide — third party manufacturing & bulk supply

Linaclotide 72 mcg, 145 mcg, 290 mcg is available through PharmaTradz for wholesale and bulk supply as well as on a third party (contract) manufacturing basis. Buyers sourcing this product generally take one of three routes:

Wholesale / bulk supply Stock or scheduled supply from an existing manufacturer. The fastest route where the product is already registered in your market.

Third party manufacturing Manufactured to your specification and packed under your own brand and label — suits distributors and brand owners building a portfolio in their market.

Dossier licensing Where a CTD, EU-CTD or ACTD dossier exists it can often be licensed for filing in your name, compressing market entry from years to months.

Indicative minimum order quantity

Linaclotide is supplied as Capsules — an oral solid dosage form, so the indicative MOQ is 200,000 units. Actual MOQ is confirmed by the allocated manufacturer against your pack presentation and destination market. See full supply terms for dossier formats, market availability and shelf life.

Manufacturers of Linaclotide listed on PharmaTradz hold site-level approvals across WHO-GMP, EU-GMP, USFDA, ANVISA and TGA, verified at onboarding.

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