Galantamine Hydrobromide Suppliers & Bulk Manufacturers

Available Forms: Tablets, Capsules

Available Strengths: 4 mg, 8 mg, 12 mg, 16 mg, 24 mg

Reference Brands: Razadyne (USA), Reminyl (EU)

Category: Neurology

Galantamine is used to treat mild to moderate Alzheimer’s disease and other forms of dementia by improving cognitive function. It works as a reversible acetylcholinesterase inhibitor and also modulates nicotinic receptors to enhance cholinergic neurotransmission in the brain. This dual mechanism helps improve memory, awareness, and the ability to perform daily activities.

Product Description:

Galantamine is a reversible, competitive acetylcholinesterase inhibitor with a second action: it is an allosteric modulator at nicotinic acetylcholine receptors, increasing their response to acetylcholine. Whether that dual mechanism adds clinical benefit over donepezil or rivastigmine has not been shown in head-to-head trials; in practice the three are broadly interchangeable for symptomatic treatment of mild to moderate Alzheimer's disease, and choice turns on tolerability and dosing.

The immediate-release tablet is taken twice daily and the prolonged-release capsule once daily, titrated in four-week steps from 8 mg to 16 or 24 mg. Slow titration matters: nausea, vomiting and weight loss are the main reasons patients stop. Bradycardia, heart block and syncope follow from cholinergic effects on the heart. Severe skin reactions have been reported. It is metabolised by CYP2D6 and CYP3A4, so exposure rises with paroxetine or ketoconazole.

Sourcing notes. Generic and inexpensive. Galantamine was first isolated from snowdrop and is now produced either by extraction from cultivated daffodils or by total synthesis; the route affects the impurity profile, which should be matched to the reference monograph. The prolonged-release capsule is a separate product needing its own dissolution specification and bioequivalence data. The oral solution serves patients who cannot swallow tablets.