Frovatriptan Succinate 2.5 mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 2.5 mg

Reference Brands: Frova (USA/EU), Migard (USA/EU)

Category: Neurology

Frovatriptan is a selective serotonin (5-HT1) receptor agonist used to treat acute migraine attacks with or without aura. It works by narrowing blood vessels in the brain and reducing substances that trigger headache, nausea, and sensitivity to light and sound during a migraine episode.

Product Description:

Frovatriptan is a 5-HT1B/1D agonist with the longest half-life of any triptan — about twenty-six hours, compared with two hours for sumatriptan. The price of that half-life is a slower onset and lower pain-free rates at two hours than faster triptans achieve. The gain is a lower headache recurrence rate, and that makes frovatriptan the choice for long attacks where the headache returns after other triptans have worn off.

The long half-life also underpins its best-supported specialised use: short-term prevention of menstrually related migraine, taken for six days around the predictable window of an attack. It is taken at headache onset for acute treatment, with a second dose permitted after two hours and a daily maximum. Its tolerability is favourable, with a low rate of triptan sensations. Contraindications are the standard triptan set — ischaemic heart disease, cerebrovascular disease, uncontrolled hypertension, hemiplegic or basilar migraine.

Sourcing notes. Off patent, with generic 2.5 mg tablets in the US and Europe. There is a single strength, which keeps manufacturing and registration simple. Frovatriptan is less widely registered than sumatriptan or rizatriptan, so buyers in emerging markets will often find the registration dossier, not price, is the step that takes time, and a bioequivalence study against the reference product is usually required.