Thioguanine 40 mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 40 mg

Reference Brands: Tabloid (USA), Lanvis (EU)

Category: Oncology Cancer Care

Tioguanine (thioguanine) tablets, an oral thiopurine antimetabolite used in acute myeloid and lymphoblastic leukaemia protocols. For hospital haematology pharmacies, importers and specialist distributors.

Product Description:

Tioguanine, also written thioguanine or 6-thioguanine, is a thiopurine antimetabolite. Cells convert it into thioguanine nucleotides that are built into DNA and RNA, which stops leukaemic cells from dividing. It is a close relative of mercaptopurine but is activated by a shorter route, which changes both its potency and its liver risk. It is an oral tablet of 40 mg, the strength marketed in the major reference markets.

It is used mainly in acute myeloid leukaemia, in induction and consolidation, and in some acute lymphoblastic leukaemia protocols, alongside other cytotoxics. It is not recommended for long-term continuous maintenance because of hepatic veno-occlusive disease and nodular regenerative hyperplasia. Patients with low TPMT or NUDT15 activity accumulate toxic nucleotides and need much smaller doses, so many centres test first. Blood counts and liver function are watched closely. Cross-resistance with mercaptopurine is usually complete. Carers wear gloves when handling the tablets.

Sourcing notes. Global supply of tioguanine has been patchy, with few finished-product sources, so plan stock well ahead and consider named-patient import where it is not registered. The tablets need no cold chain; keep them dry at room temperature in the original container. Ask for the CoA for each batch, the GMP certificate and a CoPP, and check that the label carries cytotoxic warnings in the language your market needs. It is a prescription-only cytotoxic medicine. Give the exact strength and pack count in your enquiry.