Sugammadex Sodium 100 mg/mL Suppliers & Bulk Manufacturers

Available Forms: Injection

Available Strengths: 100 mg/mL

Reference Brands: Bridion (USA)

Category: Anaesthetics

Sugammadex Sodium is a Anaesthetics product available as Injection in strengths 100 mg/mL. It corresponds to the reference brand Bridion (USA). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Sugammadex sodium is the sodium salt form of sugammadex, a biologically inert and highly selective relaxant binding agent (SRBA) used for the rapid reversal of neuromuscular blockade induced by steroidal non-depolarizing neuromuscular blocking drugs. Structurally, it is a modified anionic gamma-cyclodextrin derivative with a hydrophilic outer surface and a lipophilic central cavity, specifically designed to encapsulate target molecules.

After intravenous administration, sugammadex selectively and reversibly binds to aminosteroid neuromuscular blocking agents such as rocuronium and vecuronium. Its negatively charged carboxyl-thio-ether side chains interact with the positively charged quaternary nitrogen of these agents, forming a tight inclusion complex. This encapsulation reduces the free concentration of the neuromuscular blocker in plasma, creating a concentration gradient that draws the drug away from nicotinic acetylcholine receptors at the neuromuscular junction. As a result, normal neuromuscular transmission is rapidly restored without relying on acetylcholinesterase inhibition.

Sugammadex sodium is widely used in anesthesia practice due to its rapid onset, predictable reversal, and favorable safety profile. It enables faster recovery of muscle function, improves operating room efficiency, and reduces complications associated with residual neuromuscular blockade, making it a valuable agent in modern perioperative care.