Bivalirudin 250 mg Suppliers & Bulk Manufacturers

Available Forms: Injection

Available Strengths: 250 mg

Reference Brands: Angiomax (USA)

Category: Anaesthetics

Bivalirudin is a Anaesthetics product available as Injection in strengths 250 mg. It corresponds to the reference brand Angiomax (USA). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Bivalirudin is a direct thrombin inhibitor widely used in the management of patients undergoing percutaneous coronary intervention (PCI), particularly in cases of acute myocardial infarction. It plays a critical role in preventing thrombus formation during interventional cardiac procedures by providing rapid, predictable, and controllable anticoagulation. In addition to its established use in PCI, bivalirudin has broader clinical applications, including the management of thromboembolic disorders, cardiopulmonary bypass procedures, and extracorporeal membrane oxygenation, where precise anticoagulant control is essential.

Chemically, bivalirudin is a short, synthetic peptide derived from hirudin, a naturally occurring anticoagulant found in the saliva of the medicinal leech Hirudo medicinalis. It acts by directly and reversibly binding to thrombin, inhibiting both circulating and clot-bound thrombin, as well as thrombin-mediated platelet activation and aggregation. Unlike indirect thrombin inhibitors such as heparin, bivalirudin does not require antithrombin as a cofactor, does not bind to plasma proteins or red blood cells, and does not activate platelets.

Bivalirudin has a rapid onset of action and a short half-life, resulting in a predictable antithrombotic response. Importantly, it carries no risk of heparin-induced thrombocytopenia, making it a reliable alternative to heparin in high-risk patients.