Sepiapterin 1000 mg, 250 mg Suppliers & Bulk Manufacturers

Available Forms: Tablets / oral powder

Available Strengths: 1000 mg, 250 mg

Reference Brands: Sephience (USA/EU)

Category: Orphan Drugs

Sepiapterin is a Orphan Drugs product available as Tablets / oral powder in strengths 1000 mg, 250 mg. It corresponds to the reference brand Sephience (USA/EU). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Sepiapterin is a phenylalanine hydroxylase activator used for the treatment of hyperphenylalaninemia, including phenylketonuria (PKU). Marketed under the brand name Sephience, Sepiapterin supports metabolic control in patients who are unable to adequately process phenylalanine due to enzymatic deficiency. It works by enhancing the activity of phenylalanine hydroxylase, a key enzyme responsible for converting phenylalanine into tyrosine, thereby helping to reduce elevated blood phenylalanine levels.

Sepiapterin is a naturally occurring metabolite synthesized in the human body and serves as a biochemical precursor in the salvage pathway leading to the formation of tetrahydrobiopterin (BH4). BH4 is an essential cofactor required for the normal metabolism of phenylalanine and plays a critical role in the synthesis of neurotransmitter precursors derived from tyrosine and tryptophan, including dopamine and serotonin.

By restoring metabolic balance and improving enzymatic function, Sepiapterin provides a targeted therapeutic option for patients with disorders of phenylalanine metabolism. It is intended for long-term management and may be used alongside dietary control and other supportive treatments to achieve optimal metabolic outcomes.