Prolonged-Release Potassium Chloride 750mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 750mg

Reference Brands:

Category: Nephrology

Potassium Chloride extended-release tablets are indicated for the treatment and prophylaxis of hypokalemia with or without metabolic alkalosis, in patients for whom dietary management with potassium-rich foods or diuretic dose reduction is insufficient.

Product Description:

Potassium chloride in a prolonged-release tablet supplies potassium in a form that dissolves gradually along the gut rather than releasing a concentrated bolus in one place. That formulation exists for a specific safety reason: concentrated potassium is intensely irritating to mucosa, and immediate-release potassium tablets caused ulceration, bleeding and stricture of the small bowel. A wax matrix or microencapsulated form spreads the release out.

It is used to treat and prevent potassium depletion, commonly caused by loop and thiazide diuretics, and by vomiting, diarrhoea and some kidney disorders. Tablets are taken with a full glass of water and with food, sitting or standing upright, and never lying down, to reduce the chance of the tablet lodging in the oesophagus. The main risk is the opposite problem: hyperkalaemia, which can be fatal. Potassium supplements are contraindicated in significant kidney impairment and with potassium-sparing diuretics, ACE inhibitors, ARBs or aldosterone antagonists unless potassium is closely monitored.

Sourcing notes. Strength is quoted both in milligrams and in milliequivalents, and both belong on any quotation, since prescribing is usually in mEq. The release mechanism is the critical quality attribute and requires its own dissolution profile and bioequivalence data.