Levorphanol Tartrate 2 mg, 4 mg, 8 mg, 2 mg/mL Suppliers & Bulk Manufacturers

Available Forms: Tablet / Injection

Available Strengths: 2 mg, 4 mg, 8 mg, 2 mg/mL

Reference Brands: Generic formulations marketed under different names

Category: Critical Care

Levorphanol Tartrate is a Critical Care product available as Tablet / Injection in strengths 2 mg, 4 mg, 8 mg, 2 mg/mL. It corresponds to the reference brand Generic formulations marketed under different names. Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Levorphanol, marketed under the brand name Levo-Dromoran, is a potent opioid analgesic used for the management of moderate-to-severe pain, including chronic, post-surgical, and cancer-related pain. It is the levorotatory enantiomer of racemorphan and is approximately eight times more potent than morphine at the μ-opioid receptor (MOR), providing effective pain relief at lower doses.

Levorphanol exerts its analgesic effects primarily through agonism of the μ-opioid receptor, while also acting on δ-opioid (DOR) and κ-opioid (KOR) receptors, as well as the nociceptin receptor (NOP). Additionally, it functions as an NMDA receptor antagonist and a serotonin-norepinephrine reuptake inhibitor (SNRI), which may enhance its analgesic and neuropathic pain-modulating properties. At very high concentrations, levorphanol can also act as a glycine and GABA receptor antagonist.

Administered orally or via injection under strict medical supervision, levorphanol provides extended pain relief due to its long half-life. Its high potency, multimodal mechanism, and efficacy in severe pain management make it a valuable therapeutic option for patients requiring step 3 opioids according to the World Health Organization pain ladder.