Levoleucovorin bulk supplier for pharma manufacturers

Levoleucovorin Suppliers & Bulk Manufacturers

Available Forms: Tablet / Injection

Available Strengths: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 175 mg, 250 mg

Reference Brands: Fusilev (USA), Khapzory (USA)

Levoleucovorin is a Oncology Cancer Care product available as Tablet / Injection in strengths 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 175 mg, 250 mg. It corresponds to the reference brands Fusilev (USA), Khapzory (USA). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

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Product Description:

Levoleucovorin is the pharmacologically active levo-isomer of leucovorin calcium, used as an adjunct in cancer chemotherapy to enhance efficacy and reduce toxicity. It is an active metabolite of folic acid that does not require metabolic conversion by dihydrofolate reductase, allowing for immediate participation in cellular folate pathways.

Levoleucovorin is primarily used to counteract the toxic effects of folic acid antagonist drugs, such as high-dose methotrexate, providing a “rescue” effect that protects healthy cells while allowing the antitumor activity of chemotherapy to continue. In combination with fluorouracil and its derivatives, levoleucovorin potentiates anticancer effects by stabilizing the binding of the drug’s active metabolite to its target enzyme, thereby prolonging the cytotoxic activity against malignant cells.

Available in both oral and injectable forms, levoleucovorin is commonly used in colorectal, gastrointestinal, and other solid tumor regimens under the supervision of oncology specialists. Its targeted mechanism allows for enhanced therapeutic outcomes while minimizing collateral damage to normal cells, making it an essential component of many folate-based chemotherapy protocols.

Levoleucovorin — third party manufacturing & bulk supply

Levoleucovorin is available through PharmaTradz for wholesale and bulk supply as well as on a third party (contract) manufacturing basis. Buyers sourcing this product generally take one of three routes:

Wholesale / bulk supply Stock or scheduled supply from an existing manufacturer. The fastest route where the product is already registered in your market.

Third party manufacturing Manufactured to your specification and packed under your own brand and label — suits distributors and brand owners building a portfolio in their market.

Dossier licensing Where a CTD, EU-CTD or ACTD dossier exists it can often be licensed for filing in your name, compressing market entry from years to months.

Indicative minimum order quantity

Levoleucovorin is supplied as Tablet / Injection — supplied in more than one dosage form, each with its own manufacturing economics, so the indicative MOQ is a minimum order value of USD 5,000 per product. Actual MOQ is confirmed by the allocated manufacturer against your pack presentation and destination market. See full supply terms for dossier formats, market availability and shelf life.

Manufacturers of Levoleucovorin listed on PharmaTradz hold site-level approvals across WHO-GMP, EU-GMP, USFDA, ANVISA and TGA, verified at onboarding.

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Frequently Asked Questions

Levoleucovorin is used as rescue therapy following high-dose methotrexate to reduce toxicity and in combination with fluorouracil to enhance its anticancer activity, particularly in colorectal cancer.

Levoleucovorin is a chemically synthesized, biologically active isomer of folinic acid (reduced folate).

Common trade names include Fusilev and Khapzory.

Fusilev and Khapzory have been marketed by companies such as Spectrum Pharmaceuticals and Acrotech Biopharma, with multiple generic manufacturers supplying levoleucovorin globally.

The complete generic name is levoleucovorin calcium, also known as levofolinic acid.

Recognized brand names include Fusilev and Khapzory.

Levoleucovorin is manufactured in GMP-approved facilities across the USA, EU, India, and other regulated pharmaceutical manufacturing regions, depending on the supplier and market.