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Levoleucovorin bulk supplier for pharma manufacturers

Levoleucovorin Suppliers & Bulk Manufacturers

Available Forms: Tablet / Injection

Available Strengths: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 175 mg, 250 mg

Reference Brands: Fusilev (USA), Khapzory (USA)

Category: Oncology Cancer Care

Levoleucovorin is available in Tablet / Injection and strengths such as 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 175 mg, 250 mg. Sourced from GMP-certified and ISO-compliant manufacturers, this API meets global pharmacopeia standards (USP/EP/JP as applicable). Ideal for pharmaceutical formulation and commercial manufacturing, Levoleucovorin is supplied in bulk quantities with complete regulatory support including DMF, COA, and MSDS.

Technical Specifications & Supply Details
Lead Time 7 to 60 days (depending on batch size & schedule)
MOQ As per manufacturer’s batch size
COA Available with every batch
Regulatory Dossier / DMF Available upon request
Export Documentation FSC, COA, Manufacturing License, Product Permission
Standards IP, BP, USP
Certifications WHO-GMP, EU-GMP, USFDA (as applicable)

Levoleucovorin can be exported to over 30 countries across Asia, Africa, Europe, and Latin America. Flexible packaging, competitive pricing, and a verified supplier network make Pharmatradz a trusted sourcing partner for pharmaceutical companies and contract manufacturers worldwide.

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📘 Sourcing Guide

Product Description:

Levoleucovorin is the pharmacologically active levo-isomer of leucovorin calcium, used as an adjunct in cancer chemotherapy to enhance efficacy and reduce toxicity. It is an active metabolite of folic acid that does not require metabolic conversion by dihydrofolate reductase, allowing for immediate participation in cellular folate pathways.

Levoleucovorin is primarily used to counteract the toxic effects of folic acid antagonist drugs, such as high-dose methotrexate, providing a “rescue” effect that protects healthy cells while allowing the antitumor activity of chemotherapy to continue. In combination with fluorouracil and its derivatives, levoleucovorin potentiates anticancer effects by stabilizing the binding of the drug’s active metabolite to its target enzyme, thereby prolonging the cytotoxic activity against malignant cells.

Available in both oral and injectable forms, levoleucovorin is commonly used in colorectal, gastrointestinal, and other solid tumor regimens under the supervision of oncology specialists. Its targeted mechanism allows for enhanced therapeutic outcomes while minimizing collateral damage to normal cells, making it an essential component of many folate-based chemotherapy protocols.

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Frequently Asked Questions

Levoleucovorin is used as rescue therapy following high-dose methotrexate to reduce toxicity and in combination with fluorouracil to enhance its anticancer activity, particularly in colorectal cancer.

Levoleucovorin is a chemically synthesized, biologically active isomer of folinic acid (reduced folate).

Common trade names include Fusilev and Khapzory.

Fusilev and Khapzory have been marketed by companies such as Spectrum Pharmaceuticals and Acrotech Biopharma, with multiple generic manufacturers supplying levoleucovorin globally.

The complete generic name is levoleucovorin calcium, also known as levofolinic acid.

Recognized brand names include Fusilev and Khapzory.

Levoleucovorin is manufactured in GMP-approved facilities across the USA, EU, India, and other regulated pharmaceutical manufacturing regions, depending on the supplier and market.

Yes, Levoleucovorin is available with DMF and other regulatory documents such as COA and MSDS. These can be provided upon request for qualified buyers.

Absolutely. Sample requests are accepted for formulation trials and quality checks. Please submit an enquiry to initiate the process.

Our manufacturing partners are GMP-certified and comply with ISO and WHO standards, ensuring global quality benchmarks.

Lead times vary based on quantity and destination, but most orders are fulfilled within 1–3 weeks. Express shipping options are available.

Yes, Levoleucovorin is exported to over 30 countries across Asia, Africa, Europe, and Latin America. We support documentation for customs and regulatory clearance.

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