Levalbuterol 0.31 mg, 0.63 mg, 1.25 mg Suppliers & Bulk Manufacturers

Available Forms: Inhalation solution

Available Strengths: 0.31 mg, 0.63 mg, 1.25 mg

Reference Brands: Xopenex (USA/EU)

Category: Respiratory Disorder

Levalbuterol is a bronchodilator that relaxes muscles in the airways and increases airflow to the lungs. It is used to treat or prevent bronchospasm in patients with asthma or chronic obstructive pulmonary disease (COPD). The drug helps to relieve symptoms like wheezing, shortness of breath, and chest tightness by easing breathing during an asthma attack or before exercise.

Product Description:

Levalbuterol is the R-enantiomer of albuterol, isolated from the racemic mixture. Albuterol as conventionally supplied contains equal parts R- and S-enantiomer; the R form carries essentially all the bronchodilator activity, while the S form was historically assumed inert and later suggested to contribute to airway irritation. Levalbuterol was developed on the proposition that removing the S-enantiomer would improve the therapeutic ratio.

In practice the clinical advantage has proved modest. Comparative studies have not consistently demonstrated meaningful superiority over racemic albuterol at equivalent bronchodilator dose, and guidelines generally treat them as therapeutically similar. Levalbuterol is materially more expensive.

It is supplied as inhalation solution at 0.31, 0.63 and 1.25 mg per 3 mL and as a metered-dose inhaler.

Sourcing notes. Chiral separation makes the API more costly to produce than racemic albuterol, and that difference persists through to finished product. Where a tender specifies levalbuterol, confirm whether the requirement is genuinely for the single enantiomer or whether racemic albuterol would satisfy it — the cost difference is substantial and the clinical case for the premium is not strong. Where levalbuterol is genuinely required, note that dose equivalence is not one-to-one with racemic albuterol and specifications should state which is meant.