Dutasteride + Tamsulosin 0.5 mg + 0.4 mg Suppliers & Bulk Manufacturers

Available Forms: Capsules

Available Strengths: 0.5 mg + 0.4 mg

Reference Brands: Jalyn (USA), Dutamul (India), Duodart (EU)

Category: Urology

Dutasteride + Tamsulosin is a Urology product available as Capsules in strengths 0.5 mg + 0.4 mg. It corresponds to the reference brands Jalyn (USA), Dutamul (India), Duodart (EU). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Fixed-dose dutasteride/tamsulosin is a combination therapy used for the treatment of lower urinary tract symptoms (LUTS) secondary to benign prostatic enlargement (BPE). This formulation contains two active ingredients: tamsulosin and dutasteride. Tamsulosin is an α-adrenoceptor blocker that is relatively selective for the α1A-adrenoceptor subtype in the smooth muscles of the prostate, bladder neck, and prostatic urethra. By inhibiting these receptors, tamsulosin promotes relaxation of smooth muscle, improving urinary flow and relieving symptoms such as weak stream, hesitancy, and frequent urination.

Dutasteride is a 5α-reductase inhibitor that blocks the conversion of testosterone to dihydrotestosterone (DHT) in the prostate, liver, and skin. By reducing DHT levels, dutasteride causes shrinkage of prostatic epithelium and decreases overall prostate size, addressing the structural component of BPE.

Although no clinical studies have specifically evaluated the fixed-dose combination tablet, multiple trials on combination therapy of 5α-reductase inhibitors and α-adrenoceptor blockers, including the CombAT study, have shown significant improvements in LUTS symptom scores compared to monotherapy with either agent. This evidence supports the rationale for combining dutasteride and tamsulosin into a single tablet, offering both symptomatic relief and long-term reduction in prostate size in men with BPE.