Brinzolamide 10 mg/mL Suppliers & Bulk Manufacturers

Available Forms: Eye Drops

Available Strengths: 10 mg/mL

Reference Brands: Azopt (USA/EU)

Category: Opthalmology

Brinzolamide is a topical (ophthalmic) carbonic anhydrase inhibitor used to reduce elevated intraocular pressure (IOP) in conditions such as open-angle glaucoma and ocular hypertension. It works by inhibiting the enzyme carbonic anhydrase in the eye, thereby reducing aqueous humour production and helping lower IOP.

Product Description:

Brinzolamide is a topical carbonic anhydrase inhibitor. Blocking carbonic anhydrase II in the ciliary epithelium reduces bicarbonate formation, and with it the osmotic gradient that drives aqueous humour secretion, so less fluid is produced and pressure falls. It is the suspension counterpart to dorzolamide, and the difference between them is practical rather than pharmacological: brinzolamide is formulated at near-neutral pH, so it stings far less on instillation, at the cost of transient blurring because it is a suspension.

It is used two or three times daily for open-angle glaucoma and ocular hypertension, alone or added to another agent. Temporary blurred vision after each drop is the characteristic complaint, along with a bitter taste as drug drains into the throat. It is a sulfonamide, so it is avoided in patients with serious sulfonamide hypersensitivity, and systemic absorption means caution in severe renal impairment.

Sourcing notes. A suspension, so resuspendability, particle size and shake-before-use labelling are critical quality attributes, and settling on storage is the common failure. Off patent, with generics available. Fixed combinations with timolol and with brimonidine are separate registrations.