Avacopan 10 mg Suppliers & Bulk Manufacturers

Available Forms: Capsules

Available Strengths: 10 mg

Reference Brands: Tavneos (USA/EU)

Category: Immune Disorder

Avacopan is a Immune Disorder product available as Capsules in strengths 10 mg. It corresponds to the reference brand Tavneos (USA/EU). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Avacopan is a targeted immunomodulatory medicine sold under the brand name Tavneos and is used in the treatment of anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis. This includes serious autoimmune conditions such as granulomatosis with polyangiitis and microscopic polyangiitis. It is prescribed for adults with severe active disease and is used together with standard background therapy, including glucocorticoids and other immunosuppressive agents.

Avacopan works as a selective complement 5a (C5a) receptor antagonist. By blocking the C5a receptor on neutrophils, it reduces complement-driven inflammation and prevents excessive activation and migration of these immune cells to blood vessel walls. This helps limit vascular inflammation and tissue damage associated with ANCA-associated vasculitis. In addition to its primary mechanism, avacopan also acts as a cytochrome P450 3A4 inhibitor, which is an important consideration for potential drug interactions.

Through its targeted pathway, avacopan provides a steroid-sparing treatment approach and represents an important advancement in the management of severe ANCA-associated vasculitis.