Sebetralstat 300mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 300mg

Reference Brands: Ekterly (USA)

Category: Immune Disorder

Sebetralstat is an oral plasma kallikrein inhibitor used for the on-demand treatment of hereditary angioedema (HAE) attacks in adults and adolescents. It reduces bradykinin production, which helps control swelling episodes caused by HAE.

Product Description:

Sebetralstat is an oral inhibitor of plasma kallikrein. In hereditary angioedema, deficient C1 esterase inhibitor lets kallikrein generate bradykinin unchecked, and bradykinin makes blood vessels leak, producing attacks of swelling in the skin, abdomen and airway. Sebetralstat blocks the enzyme directly, stopping bradykinin production and halting the attack.

It is used for acute attacks in patients aged twelve and over. Its significance is the route: until its approval, every on-demand HAE treatment was an injection or infusion, which meant patients delayed treatment — carrying a syringe, finding a private place, managing needles during an abdominal attack — and delay makes attacks longer and more dangerous. An oral tablet taken at the first symptom removes that barrier, and trials showed faster symptom relief than placebo with a second dose permitted if needed. It does not prevent attacks; patients on prophylaxis still need it for breakthrough episodes. It is well tolerated, with headache the most reported effect.

Sourcing notes. Originator product, approved in 2025, on patent, no generic. As a tablet it needs no cold chain — unusual in this therapeutic area and a genuine distribution advantage in hot climates and for patients who travel. Supply is through authorised distribution.