Almotriptan Malate bulk supplier for pharma manufacturers

Almotriptan Malate 6.25 mg,12.5 mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 6.25 mg,12.5 mg

Reference Brands: Axert (USA), Almogran (EU/UK)

Category: Neurology

Almotriptan is a 5-HT₁B/₁D receptor agonist belonging to the triptan class of medications. It is used for the acute treatment of migraine attacks with or without aura in adults and adolescents aged 12 to 17 years. Almotriptan works by narrowing blood vessels around the brain, stopping pain signals, and reducing the release of substances that cause pain, nausea, and other symptoms of migraines.

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Product Description:

Almotriptan is a second-generation triptan, a selective 5-HT1B/1D agonist that constricts dilated meningeal vessels and inhibits release of CGRP and other neuropeptides from trigeminal nerve endings. Among the triptans it is distinguished by high oral bioavailability of about 70% and a comparatively low rate of triptan sensations — chest tightness, tingling and heaviness — which makes it a reasonable choice for patients who stopped sumatriptan because of them.

It is taken at the start of the headache phase rather than during aura, with one repeat dose permitted after two hours if the headache returns. It is eliminated by both MAO-A and CYP3A4/2D6 metabolism and by renal excretion, so the dose ceiling is lowered in severe renal impairment. Contraindications are the triptan class set: ischaemic heart disease, cerebrovascular disease, uncontrolled hypertension and hemiplegic or basilar migraine.

Sourcing notes. Off patent with generic tablets registered in the US and across Europe, so this is competitive commodity supply. The 12.5 mg tablet carries nearly all the volume; 6.25 mg exists mainly for renal and hepatic dose adjustment. Buyers in markets where sumatriptan is the only registered triptan often find registration, not price, is the limiting step, and a reference-product bioequivalence study will usually be required. The malate salt is standard; confirm the pharmacopoeial monograph the destination market expects.

Almotriptan Malate — third party manufacturing & bulk supply

Almotriptan Malate 6.25 mg,12.5 mg is available through PharmaTradz for wholesale and bulk supply as well as on a third party (contract) manufacturing basis. Buyers sourcing this product generally take one of three routes:

Wholesale / bulk supply Stock or scheduled supply from an existing manufacturer. The fastest route where the product is already registered in your market.

Third party manufacturing Manufactured to your specification and packed under your own brand and label — suits distributors and brand owners building a portfolio in their market.

Dossier licensing Where a CTD, EU-CTD or ACTD dossier exists it can often be licensed for filing in your name, compressing market entry from years to months.

Indicative minimum order quantity

Almotriptan Malate is supplied as Tablets — an oral solid dosage form, so the indicative MOQ is 200,000 units. Actual MOQ is confirmed by the allocated manufacturer against your pack presentation and destination market. See full supply terms for dossier formats, market availability and shelf life.

Manufacturers of Almotriptan Malate listed on PharmaTradz hold site-level approvals across WHO-GMP, EU-GMP, USFDA, ANVISA and TGA, verified at onboarding.

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Frequently Asked Questions

Almotriptan Malate is listed as Tablets in 6.25 mg,12.5 mg. Further strengths and pack presentations are confirmed with the manufacturer at RFQ stage.

Almotriptan Malate is referenced against Axert (USA), Almogran (EU/UK). Reference brands are shown for identification only and remain the property of their respective trademark owners.