Adapalene Gel (0.1%, 0.3%) Suppliers & Bulk Manufacturers

Available Forms: Gel

Available Strengths: (0.1%, 0.3%)

Reference Brands: Differin(US)

Category: Derma Drugs

Adapalene gel 0.1% and 0.3%, a topical retinoid used for acne vulgaris, supplied in tubes. For importers, distributors, dermatology pharmacies and hospital buyers who need registered generic or OTC supply.

Product Description:

Adapalene is a topical retinoid, a synthetic naphthoic acid derivative that binds selectively to retinoic acid receptors in the skin. It normalises how follicle-lining cells mature and shed, which stops new comedones forming, and it has a mild anti-inflammatory effect. This page covers an aqueous gel at 0.1% and 0.3%, with micronised adapalene suspended in the gel base. A water-based gel spreads thinly, dries without greasiness and suits oily skin.

Adapalene gel is used for acne vulgaris with comedones, papules and pustules, on the face, chest or back. A thin layer is applied once daily in the evening to clean, dry skin, avoiding the eyes, lips and broken skin. Dryness, redness and stinging are common in the first weeks and usually settle. Patients should use sunscreen and limit sun exposure. Topical retinoids are not recommended in pregnancy. The 0.1% gel is sold without prescription in some markets, including the United States, while the 0.3% strength stays prescription-only.

Sourcing notes. Adapalene gel is a medicine, so the dossier follows normal CTD or ACTD rules. Regulators handle equivalence for topical generics in different ways, so ask what the dossier contains. Particle size control of the suspended drug, viscosity, pH and assay on every batch CoA are key specifications. Laminated or aluminium tubes are usual, stored at room temperature and kept from freezing. Ask for stability data covering Zone IVb where needed, the GMP certificate and a CoPP. Your enquiry should state the strength, tube size, label language and prescription status in the destination market.