Sorafenib bulk supplier for pharma manufacturers

Sorafenib 200 mg Suppliers & Bulk Manufacturers

Available Forms: Tablet

Available Strengths: 200 mg

Reference Brands: Nexavar (US & EU)

Sorafenib 200 mg film-coated tablets, an oral multikinase inhibitor for advanced liver, kidney and thyroid cancers. For oncology importers, distributors, hospital pharmacies and tender buyers.

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Product Description:

Sorafenib is an oral multikinase inhibitor. It blocks RAF kinases in the cell growth pathway and the VEGF and PDGF receptors that drive new blood vessel formation, so it acts on both tumour cells and their blood supply. This page covers 200 mg film-coated tablets. Because the whole course is taken by mouth at home, it suits outpatient oncology clinics and hospital pharmacies that dispense long-term targeted therapy.

Approved uses are unresectable hepatocellular carcinoma, advanced renal cell carcinoma and differentiated thyroid carcinoma no longer responding to radioactive iodine. The usual adult dose is 400 mg twice daily, without food or with a low-fat meal. Hand-foot skin reaction, diarrhoea, fatigue and raised blood pressure are common. Bleeding, poor wound healing and QT prolongation are recognised precautions, and treatment is paused before major surgery. Strong CYP3A4 inducers such as rifampicin lower exposure, and warfarin users need closer INR checks.

Sourcing notes. Sorafenib is a prescription-only anticancer medicine, and many hospitals handle it under hazardous-drug procedures, so staff should not crush or split tablets. Aluminium blisters at room temperature are usual, with no cold chain. For hot humid markets, ask for stability data at zone IVb (30 °C, 75% relative humidity). Request a CTD or ACTD dossier, a CoA for each batch, the GMP certificate and a CoPP. For a generic, ask for the bioequivalence study and data on the crystal form of the tosylate salt. State tablets per pack, shelf life at delivery and label language.

Sorafenib — third party manufacturing & bulk supply

Sorafenib 200 mg is available through PharmaTradz for wholesale and bulk supply as well as on a third party (contract) manufacturing basis. Buyers sourcing this product generally take one of three routes:

Wholesale / bulk supply Stock or scheduled supply from an existing manufacturer. The fastest route where the product is already registered in your market.

Third party manufacturing Manufactured to your specification and packed under your own brand and label — suits distributors and brand owners building a portfolio in their market.

Dossier licensing Where a CTD, EU-CTD or ACTD dossier exists it can often be licensed for filing in your name, compressing market entry from years to months.

Indicative minimum order quantity

Sorafenib is supplied as Tablet — an oral solid dosage form, so the indicative MOQ is 200,000 units. Actual MOQ is confirmed by the allocated manufacturer against your pack presentation and destination market. See full supply terms for dossier formats, market availability and shelf life.

Manufacturers of Sorafenib listed on PharmaTradz hold site-level approvals across WHO-GMP, EU-GMP, USFDA, ANVISA and TGA, verified at onboarding.

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Frequently Asked Questions

Sorafenib tosylate is used for the treatment of certain types of cancer, including hepatocellular carcinoma (liver cancer), advanced renal cell carcinoma (kidney cancer), and radioactive iodine-refractory differentiated thyroid carcinoma. It works by slowing tumor cell growth and reducing tumor blood vessel formation.

Sorafenib is made from the active pharmaceutical ingredient sorafenib tosylate, a multikinase inhibitor that blocks tumor cell proliferation and angiogenesis by targeting multiple intracellular and cell surface kinases.

The main international trade name is Nexavar.

The original branded product Nexavar is developed and marketed by Bayer. Generic sorafenib products are manufactured by multiple pharmaceutical companies worldwide after patent expiry in several regions.

The complete generic name is sorafenib tosylate.

The primary brand name is Nexavar.

Sorafenib tablets are manufactured in multiple countries including the USA, EU, UK, and India by Bayer and various GMP-certified generic manufacturers for global oncology supply.