Sonidegib 200 mg Suppliers & Bulk Manufacturers

Available Forms: Capsules

Available Strengths: 200 mg

Reference Brands: Odomzo (USA/EU)

Category: Oncology Cancer Care

Sonidegib 200 mg capsules, an oral hedgehog pathway (Smoothened) inhibitor for locally advanced basal cell carcinoma unsuitable for surgery or radiotherapy. For hospital pharmacies, oncology buyers and importers.

Product Description:

Sonidegib is an oral inhibitor of the hedgehog signalling pathway. It blocks Smoothened, a membrane protein that, when the pathway is switched on abnormally, drives the growth of most basal cell carcinomas. It comes as 200 mg hard capsules containing sonidegib as the phosphate salt, taken once daily. It gives a medical option for skin cancers no longer suited to surgery or radiotherapy.

It is used for adults with locally advanced basal cell carcinoma who are not candidates for curative surgery or radiation therapy. The capsule is taken on an empty stomach, at least one hour before or two hours after a meal, because food increases absorption markedly. The most serious risk is harm to an unborn child, so women of childbearing potential follow a pregnancy prevention programme, men use condoms, and patients do not donate blood during and after treatment. Muscle spasms, raised creatine kinase, hair loss and taste change are common, and creatine kinase is checked regularly. Co-prescribing strong CYP3A inhibitors or inducers is avoided.

Sourcing notes. Registration exists in the United States, the European Union and some other markets; elsewhere supply runs through named-patient routes. The capsules are kept at room temperature in the original pack, with no cold chain. Because of the pregnancy risk, packs must carry the approved leaflet and patient card in the local language, so check labelling before ordering. Ask for the batch CoA, GMP certificate and CoPP, and serialised original packs. It is prescription-only, used by dermatologists and oncologists. State pack size and monthly quantity.