What is palonosetron made from?

Palonosetron is a chemically synthesized compound that belongs to the class of serotonin (5-HTâ) receptor antagonists. It works by blocking serotonin receptors involved in triggering nausea and vomiting.

Palonosetron Injection bulk supplier for pharma manufacturers

Palonosetron Injection 0.25 mg/5 mL (0.05 mg/mL) Suppliers & Bulk Manufacturers

Available Forms: IV Injection

Available Strengths: 0.25 mg/5 mL (0.05 mg/mL)

Reference Brands: Aloxi (US & EU)

Category: Oncology Cancer Care

Palonosetron Injection is a long-acting antiemetic used to prevent CINV and PONV, available as 0.25 mg/5 mL and 0.075 mg/mL IV doses. Marketed under Aloxi® in the US and EU, it offers extended protection and is ideal for oncology settings. GMP-compliant and available in both branded and generic forms, Palonosetron is a reliable choice for pharma partners across Europe and North America.

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Product Description:

Palonosetron Injection is a next-generation 5-HT3 receptor antagonist used to prevent chemotherapy-induced and post-operative nausea and vomiting (CINV & PONV). Known for its long half-life and superior efficacy, Palonosetron provides extended protection against both acute and delayed emesis. It is available in 0.25 mg/5 mL and 0.075 mg/mL IV formulations, ideal for hospital and oncology settings. Marketed under Aloxi® in the US and EU, and also offered in generic form, it is manufactured under GMP-certified conditions. Palonosetron is a preferred antiemetic for pharmaceutical distributors seeking reliable oncology support across Europe and North America.

Palonosetron Injection — third party manufacturing & bulk supply

Palonosetron Injection 0.25 mg/5 mL (0.05 mg/mL) is available through PharmaTradz for wholesale and bulk supply as well as on a third party (contract) manufacturing basis. Buyers sourcing this product generally take one of three routes:

Wholesale / bulk supply Stock or scheduled supply from an existing manufacturer. The fastest route where the product is already registered in your market.

Third party manufacturing Manufactured to your specification and packed under your own brand and label — suits distributors and brand owners building a portfolio in their market.

Dossier licensing Where a CTD, EU-CTD or ACTD dossier exists it can often be licensed for filing in your name, compressing market entry from years to months.

Indicative minimum order quantity

Palonosetron Injection is supplied as IV Injection — an injectable dosage form, so the indicative MOQ is 50,000 units. Actual MOQ is confirmed by the allocated manufacturer against your pack presentation and destination market. See full supply terms for dossier formats, market availability and shelf life.

Manufacturers of Palonosetron Injection listed on PharmaTradz hold site-level approvals across WHO-GMP, EU-GMP, USFDA, ANVISA and TGA, verified at onboarding.

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Frequently Asked Questions

Palonosetron is used to prevent nausea and vomiting associated with cancer chemotherapy and surgical procedures. It is particularly effective in preventing delayed nausea and vomiting that may occur several hours to days after treatment.

Palonosetron is a chemically synthesized compound that belongs to the class of serotonin (5-HT₃) receptor antagonists. It works by blocking serotonin receptors involved in triggering nausea and vomiting.

Palonosetron is marketed under the trade name Aloxi.

The original brand Aloxi was developed and marketed by Helsinn Healthcare. Today, palonosetron is also manufactured by multiple pharmaceutical companies worldwide as branded and generic versions.

The generic name is palonosetron (commonly used as palonosetron hydrochloride).

The most well-known brand name is Aloxi, along with various country-specific branded generics.

Palonosetron is manufactured in several countries including the USA, EU nations, India, and other regulated markets by approved pharmaceutical manufacturers following international quality and regulatory standards.